Identification of a distinct association fiber tract “IPS-FG” to connect the intraparietal sulcus areas and fusiform gyrus by white matter dissection and tractography

Jitsuishi, Tatsuya; Yamaguchi, Atsushi

doi:10.1038/s41598-020-72471-z

Cited by 10 publications

(4 citation statements)

References 57 publications

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“…The human dorsal and ventral streams are connected by a fiber tract arising from medial bank of the intraparietal sulcus (IPS) connecting the IPS with the fusiform gyrus in the ventral temporal cortex. This connection was believed to mediate sensorimotor integration in visually guided behavior [125]. The angular gyrus, the supramarginal gyrus, and the banks of the intraparietal sulcus (IPS) of the human brain are subdivisions of the inferior parietal lobe (IPL), which is situated at the junction of the temporal, parietal, and occipital lobes.…”

Section: Two Visual Systemsmentioning

confidence: 99%

Is Developmental Dyslexia Due to a Visual and Not a Phonological Impairment?

Werth¹

2021

Brain Sciences

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It is a widely held belief that developmental dyslexia (DD) is a phonological disorder in which readers have difficulty associating graphemes with their corresponding phonemes. In contrast, the magnocellular theory of dyslexia assumes that DD is a visual disorder caused by dysfunctional magnocellular neural pathways. The review explores arguments for and against these theories. Recent results have shown that DD is caused by (1) a reduced ability to simultaneously recognize sequences of letters that make up words, (2) longer fixation times required to simultaneously recognize strings of letters, and (3) amplitudes of saccades that do not match the number of simultaneously recognized letters. It was shown that pseudowords that could not be recognized simultaneously were recognized almost without errors when the fixation time was extended. However, there is an individual maximum number of letters that each reader with DD can recognize simultaneously. Findings on the neurobiological basis of temporal summation have shown that a necessary prolongation of fixation times is due to impaired processing mechanisms of the visual system, presumably involving magnocells and parvocells. An area in the mid-fusiform gyrus also appears to play a significant role in the ability to simultaneously recognize words and pseudowords. The results also contradict the assumption that DD is due to a lack of eye movement control. The present research does not support the assumption that DD is caused by a phonological disorder but shows that DD is due to a visual processing dysfunction.

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Section: Two Visual Systemsmentioning

confidence: 99%

Is Developmental Dyslexia Due to a Visual and Not a Phonological Impairment?

Werth¹

2021

Brain Sciences

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“…A voxel-based lesion-symptom mapping study in human subjects showed that the parietal operculum, insular cortex, putamen, and subcortical projections to the prefrontal cortex were involved in the perception of touch [7]. In addition, some reports showed that the insular cortex also integrates cognitive and sensory perceptions of cutaneous stimuli [7], and that the intraparietal sulcus is an interface for sensorimotor integration in visually guided actions [18], with the angular and supramaginal gyrus together with the temporo-parieto-occipital (TPO) junction participating in spatial cognition [19]. Therefore, these brain regions may play an important role in body illusion.…”

Section: Discussionmentioning

confidence: 99%

Limb loss experience evoked by electric cortical stimulation

Hao¹,

Wang²,

Yan³

et al. 2022

Epileptic Disorders

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Objective. Limb loss experience is a type of body illusion characterized by the sensation of a missing limb or body part. We aimed to investigate the brain areas involved in this unusual somatosensory experience evoked by electric cortical stimulation with stereo‐electroencephalography electrodes. Methods. We retrospectively reviewed the data of patients with medical intractable epilepsy, from October 2015 to December 2020, who underwent stereo‐electroencephalography implantation and electric cortical stimulation in order to locate the epileptogenic zone and obtain a functional map. We included patients who reported experiences of limb loss during the process of electric cortical stimulation for functional mapping. Results. Three patients reported experiences of limb loss in the process of electric cortical stimulation. Limb loss experience (including the right hand, right upper limb and right side of the body) occurred when the cortex of the left posterior insula, posterior dorsal cingulate and parietal operculum were stimulated. Significance. Limb loss experience can be evoked by electric cortical stimulation of the posterior insula, parietal operculum, and posterior cingulate cortex, and provides additional evidence that these cortices play a role in the integration of body sensory perception.

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“…Deterministic fiber tracking was conducted as previously described 34 , 35 . Briefly, the reconstruction of tractography was performed by ROI (region of interest)-based approach with DSI Studio ( http://dsi-studio.labsolver.org ).…”

Section: Methodsmentioning

confidence: 99%

“…The quantitative tractography analysis was conducted, in which the ‘connectivity matrix’ function in DSI Studio was used to generate matrices representing the number of fibers ending in regions of a per-subject aligned HCP MMP1.0 atlas. After the bilateral connectivity matrices were generated, the number of streamlines corresponding to each connection was divided by the total number of each tract 34 , 35 .…”

Section: Methodsmentioning

confidence: 99%

Searching for optimal machine learning model to classify mild cognitive impairment (MCI) subtypes using multimodal MRI data

Jitsuishi

Yamaguchi

2022

Sci Rep

Self Cite

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The intervention at the stage of mild cognitive impairment (MCI) is promising for preventing Alzheimer’s disease (AD). This study aims to search for the optimal machine learning (ML) model to classify early and late MCI (EMCI and LMCI) subtypes using multimodal MRI data. First, the tract-based spatial statistics (TBSS) analyses showed LMCI-related white matter changes in the Corpus Callosum. The ROI-based tractography addressed the connected cortical areas by affected callosal fibers. We then prepared two feature subsets for ML by measuring resting-state functional connectivity (TBSS-RSFC method) and graph theory metrics (TBSS-Graph method) in these cortical areas, respectively. We also prepared feature subsets of diffusion parameters in the regions of LMCI-related white matter alterations detected by TBSS analyses. Using these feature subsets, we trained and tested multiple ML models for EMCI/LMCI classification with cross-validation. Our results showed the ensemble ML model (AdaBoost) with feature subset of diffusion parameters achieved better performance of mean accuracy 70%. The useful brain regions for classification were those, including frontal, parietal lobe, Corpus Callosum, cingulate regions, insula, and thalamus regions. Our findings indicated the optimal ML model using diffusion parameters might be effective to distinguish LMCI from EMCI subjects at the prodromal stage of AD.

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Identification of a distinct association fiber tract “IPS-FG” to connect the intraparietal sulcus areas and fusiform gyrus by white matter dissection and tractography

Cited by 10 publications

References 57 publications

Is Developmental Dyslexia Due to a Visual and Not a Phonological Impairment?

Is Developmental Dyslexia Due to a Visual and Not a Phonological Impairment?

Limb loss experience evoked by electric cortical stimulation

Searching for optimal machine learning model to classify mild cognitive impairment (MCI) subtypes using multimodal MRI data

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