Identification of a crucialINO2allele for enhancing ethanol resistance in an industrial fermentation strain ofSaccharomyces cerevisiae
Sonia Albillos-Arenal,
Javier Alonso del Real,
María Lairón-Peris
et al.
Abstract:Ethanol toxicity is a major challenge forS. cerevisiaeduring fermentation, affecting its growth and influencing the process. This study investigated the molecular mechanisms of ethanol tolerance using transcriptomic analysis of threeS. cerevisiaestrains with varying ethanol resistance. We identified distinct responses in membrane lipid synthesis genes, particularly in ergosterol biosynthesis, regulated by the Ino2p transcription factor. A variant of Ino2p with V263I and H86R amino acid replacements was exclusi… Show more
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