Identification of a 9-gene signature related to stemness for prognosis in hepatocellular carcinoma basing on weighted gene coexpression network analysis
Abstract:Background
Cancer stem cells (CSCs) are heterogeneous with self-renewal and differentiation ability. The mRNA expression-based stemness index (mRNAsi) described the similarity between tumor cells and CSCs, which is positively associated with the poor prognosis of cancer patients. However, the key prognostic genes related to mRNAsi in hepatocellular carcinoma (HCC) remains unclear.
Methods
In this study, RNA sequencing (RNA-seq) data of 374 liver HCC (LIHC) and 50 normal liver tissue samples were downloaded f… Show more
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