2002
DOI: 10.1074/jbc.m200438200
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Identification, Molecular Cloning, and Characterization of a Novel GABAA Receptor-associated Protein, GRIF-1

Abstract: A novel 913-amino acid protein, ␥-aminobutyric acid type A (GABA A ) receptor interacting factor-1 (GRIF-1), has been cloned and identified as a GABA A receptorassociated protein by virtue of its specific interaction with the GABA A receptor ␤2 subunit intracellular loop in a yeast two-hybrid assay. GRIF-1 has no homology with proteins of known function, but it is the rat orthologue of the human ALS2CR3/KIAA0549 gene. GRIF-1 is expressed as two alternative splice forms, GRIF-1a and a C-terminally truncated for… Show more

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Cited by 103 publications
(92 citation statements)
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“…The conservation in amino acid sequence between TRAK1 and TRAK2 and the similarity in their known functional properties (i.e. their direct binding to the cargo domains of KHC; their ability to co-distribute with mitochondria, resulting in the collapse of the mitochondrial network when overexpressed in cells; the redistribution of mitochondria to the tips of processes when either TRAK1 or TRAK2 are co-expressed with KHC; and the co-immunoprecipitation of Miro1 or Miro2 with either TRAK1 or TRAK2 following overexpression in mammalian cells) suggest that both proteins have similar functions (9,12,13,15,17). Yet despite the finding that TRAK1 and TRAK2 shRNAs had similar efficacies in heterologous expression, TRAK2 shRNAis had no effect on mitochondrial mobility.…”
Section: Discussionmentioning
confidence: 99%
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“…The conservation in amino acid sequence between TRAK1 and TRAK2 and the similarity in their known functional properties (i.e. their direct binding to the cargo domains of KHC; their ability to co-distribute with mitochondria, resulting in the collapse of the mitochondrial network when overexpressed in cells; the redistribution of mitochondria to the tips of processes when either TRAK1 or TRAK2 are co-expressed with KHC; and the co-immunoprecipitation of Miro1 or Miro2 with either TRAK1 or TRAK2 following overexpression in mammalian cells) suggest that both proteins have similar functions (9,12,13,15,17). Yet despite the finding that TRAK1 and TRAK2 shRNAs had similar efficacies in heterologous expression, TRAK2 shRNAis had no effect on mitochondrial mobility.…”
Section: Discussionmentioning
confidence: 99%
“…Thus, TRAK1 and TRAK2 may participate in microtubule-based transport of early endosomes by acting as an adaptor linking Hrs-containing endosomes to kinesin (20,21). TRAKs have also been linked to the forward trafficking of inhibitory GABA A neurotransmitter receptors (9,32) and Kir2.1 inwardly rectifying potassium channels (33). TRAKs may therefore be promiscuous in terms of the cargo they transport.…”
Section: Discussionmentioning
confidence: 99%
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