Identification, molecular characterization, expression analysis and wound-healing ability of multifunctional calreticulin from big-belly seahorse Hippocampus abdominalis

Immunomodulation of wound healing leading to efferocytosis

“…� Regulates angiogenesis 32 � Promotes proliferation and migration of fibroblasts 33 � Promotes collagen deposition 34 � Accelerates wound closure 35 � Regulates angiogenesis 36 � Immune cell phenotype that promotes regeneration 37 � Promotes cell proliferation 38 � Promotes collagen deposition 39 � Increased proliferation of keratinocytes and fibroblasts 40 � Regulates angiogenesis 41 Bind Eat me signal Phosphatidylserine (PtdSer) Calreticulin (CRT) Thrombospondin 1 (TSP1) Milk fat globule-EGF-factor 8 (MFG-E8) Gas6 Protein S � Participate in hemostasis 42 � Promotes the resolution of inflammation 43 � Ca 2þ homeostasis in vivo 44 � Induces migration of pro-repair cells 45 � Promotes re-epithelialization 46 � Regulates fibroblast secretion and collagen deposition 47 � Regulates cell migration and matrix remodeling 48 � Regulates blood clotting and promotes angiogenesis 49 � Promote the migration and proliferation of fibroblasts 50 � Regulates angiogenesis 51 � None Bridge molecules in the dermis, DCs, macrophages, and T cells predominate. 54 An important step in wound repair is the elimination of cell death induced by the inflammatory environment.…”