Identification, chemical synthesis, and receptor binding of a reptilian gecko ghrelin
Hidekazu Katayama,
Hiroyuki Kaiya
Abstract:Ghrelin is known to be a gastrointestinal peptide hormone in vertebrates. It has a unique posttransrational modification, octanoylation, at the Ser side chain of the third position. In this study, we identified the genes encoding ghrelin and its receptor from the Schlegel's Japanese gecko Gekko japonicus. The C‐terminal residue of gecko ghrelin was His, although the chemical synthesis method for the O‐octanoyl peptide with a C‐terminal His residue has not yet been well‐established. Acyl‐ghrelin has been synthe… Show more
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