2003
DOI: 10.1210/jc.2003-030494
|View full text |Cite
|
Sign up to set email alerts
|

Identification, Characterization, and Regulation of the Canonical Wnt Signaling Pathway in Human Endometrium

Abstract: Members of the Wnt family of signaling molecules are important in cell specification and epithelial-mesenchymal interactions, and targeted gene deletion of Wnt-7a in mice results in complete absence of uterine glands and infertility. To assess potential roles of the Wnt family in human endometrium, an endocrine-responsive tissue, we investigated in the proliferative and secretory phases of the menstrual cycle, endometrial expression of several Wnt ligands (Wnt-2, Wnt-3, Wnt-4, Wnt-5a, Wnt-7a, and Wnt-8b), rece… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

14
141
1
2

Year Published

2006
2006
2023
2023

Publication Types

Select...
9

Relationship

0
9

Authors

Journals

citations
Cited by 195 publications
(158 citation statements)
references
References 31 publications
14
141
1
2
Order By: Relevance
“…Additionally, recombinant Wnt-5a could not induce luciferase expression of the TCF reporter plasmid, suggesting that the accessory proteins required for Wnt-5a-induced canonical Wnt signalling [8] are lacking in trophoblasts. Interestingly, Wnt-5a expression has also been detected in early and late phase endometrium, suggesting that decidual expression of the ligand may exert paracrine effects on invading trophoblasts [14].…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Additionally, recombinant Wnt-5a could not induce luciferase expression of the TCF reporter plasmid, suggesting that the accessory proteins required for Wnt-5a-induced canonical Wnt signalling [8] are lacking in trophoblasts. Interestingly, Wnt-5a expression has also been detected in early and late phase endometrium, suggesting that decidual expression of the ligand may exert paracrine effects on invading trophoblasts [14].…”
Section: Discussionmentioning
confidence: 99%
“…Several mRNAs encoding Wnt ligands and FZD receptors were detected in human term placenta [9][10][11][12][13]. In addition, endometrial expression of Wnt3 and Dickkopf-1 (Dkk1), which inhibits canonical Wnt signalling by disrupting binding of LRP-5/6 to the Wnt/FZD complex, was observed [14], suggesting paracrine mechanisms regulating implantation and/or trophoblast invasion. The TCF family members TCF-3 and TCF-4 are predominantly expressed in invasive trophoblasts and activation of the canonical Wnt signalling pathway promotes trophoblast migration and invasion [15].…”
Section: Introductionmentioning
confidence: 99%
“…DKK-1 is a potent inhibitor of the Wnt signaling pathway [69]. It was recently found to be specifically up-regulated by progesterone in in vitro decidualized endometrial stromal cells [70], was up-regulated in microarray study of mid-secretory endometrium [62] and downregulated in eutopic endometrium from women with endometriosis [52].…”
Section: Transcriptomic Approaches To Markers Of Uterine Receptivitymentioning
confidence: 99%
“…It has been shown that endometrial receptivity could be modulated by a multitude of signaling molecules, including prostaglandins [3], growth factors, cytokines, chemokines, integrins, leukemia inhibitory factor [4,5], Wnt family ligands [6], and E-cadherin [7]. Whereas dysregulation of some of these factors could be associated with repeated implantation failure, key molecular mechanisms that underlie the regulation of endometrial receptivity remain to be elucidated [8].…”
Section: Introductionmentioning
confidence: 99%