Identification by NMR and MS of the by-products formed during the synthesis of the red vat dye 1,1'-diethyl-(3,3'-bianthra[1,9-c,d]pyrazole)-6,6'(1H,1'H)-dione

Alkyl chain substituted 1,9-pyrazoloanthrones exhibit prominent inhibitory effect on c-Jun N-terminal kinase (JNK)

“…1b). 29 According to Scapin and co-workers, 30 the crystal structure of JNK3 with 1,9-pyrazoloanthrone (PDB code: 1PMV) showed higher selectivity towards inhibition compared to the other molecules. It was shown that SP600125 interacts with the protein via hydrogen bonds with the carbonyl oxygen of Glu147 and the main chain nitrogen of Met149.…”

Role of the H-Bond Interactions in the Colloidal Mixtures of Pyrazole-Based Bioactive Dyes and Poly(vinyl alcohol)

“…12 Moreover, surface grafted PVA-based core−shell microspheres have been shown as drug carriers. 13 The use of pyrazole as the central core in designing dyes 3,4 and bioactive molecules with antibacterial, 14 antiobesity, 15 antidepressant, 16 and anticoagulant 17 effects has become popular in the past decade. 18−20 The electronegativity of the atom or group at the pyrazole 4-position is correlated to several bioactivities.…”

“…Especially polymeric materials based colloidal systems, despite being complex, have applications in the pharmaceutical industry . Although the design and synthesis of pyrazole derivatives have been studied extensively, their blends with polymers are rarely investigated. , In the present study, we investigate the blends of pyrazole-based dyes with poly(vinyl alcohol) (PVA) as colloidal dispersion system.…”

“…The use of pyrazole as the central core in designing dyes , and bioactive molecules with antibacterial, antiobesity, antidepressant, and anticoagulant effects has become popular in the past decade. − The electronegativity of the atom or group at the pyrazole 4-position is correlated to several bioactivities . Replacement of the pyrazole with different heterocycles demonstrates that nitrogen atoms play a major role in the H-bond formations .…”