Identification and validation of microtubule depolymerizing agent, CYT997, as a potential drug candidate for hepatocellular carcinoma
Faiz Ahmad,
Li Ma,
Wei Wei
et al.
Abstract:Background and AimsHepatocellular carcinoma (HCC) is a typically fatal malignancy with limited treatment options and poor survival rates, despite recent FDA approvals of newer treatment options. We aim to address this unmet need by using a proprietary computational drug discovery platform that identifies drug candidates with the potential to advance rapidly and successfully through preclinical studies.MethodsWe generated an in silico model of HCC biology to identify the top 10 small molecules with predicted ef… Show more
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