Identification and validation of eight estrogen-related genes for predicting prognosis of papillary thyroid cancer

Zeng, Yu; Ma, Weike; Li, Lijuan; Zhuang, Gaojian; Luo, Guoqing; Zhou, Hong; Hao, Weijing; Liu, Yu; Guo, Fei; Tian, Ming; Ruan, Xianhui; Gao, Ming; Zheng, Xiangqian

doi:10.18632/aging.204582

Cited by 2 publications

(2 citation statements)

References 35 publications

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“…Concerning estrogens and inflammation, a recent study performed a bioinformatic analysis using The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases: the authors focused on the expression of estrogen-related genes in PTC, with a special highlight on Neuromedin U (NMU), a neuropeptide involved in several physiological and pathological inflammatory processes. Interestingly, the proliferative ability of PTC cells' proliferation and KRAS pathway activation appeared significantly decreased after knockdown of the NMU gene, in line with the potential pro-tumoral, estrogenic activity on the TME within TC [75].…”

Section: Estrogens and Tmementioning

confidence: 66%

The Tumor Microenvironment and the Estrogen Loop in Thyroid Cancer

Denaro

Romanò

Alfieri

et al. 2023

Cancers

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Thyroid cancer (TC) cells employ multiple signaling pathways, such as PI3K/AKT/mTOR and RAS/Raf/MAPK, fostering cell proliferation, survival and metastasis. Through a complex interplay with immune cells, inflammatory mediators and stroma, TC cells support an immunosuppressive, inflamed, pro-carcinogenic TME. Moreover, the participation of estrogens in TC pathogenesis has previously been hypothesized, in view of the higher TC incidence observed among females. In this respect, the interactions between estrogens and the TME in TC could represent a relevant, unexplored area of research. We thereby collectively reviewed the available evidence concerning the potential carcinogenic role of estrogens in TC, specifically focusing on their crosstalk with the TME.

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Section: Estrogens and Tmementioning

confidence: 66%

The Tumor Microenvironment and the Estrogen Loop in Thyroid Cancer

Denaro

Romanò

Alfieri

et al. 2023

Cancers

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“…Recent studies have shown that the enrichment analyses of DEGs in papillary thyroid cancer and normal thyroid tissue are mainly enriched in the estrogen response pathway. As the expression of ERGs increases, the likelihood of PTC progression to advanced tumors also increases, and the overall prognosis of patients becomes poor [ 24 ]. Therefore, it is important to study how ERGs affect the clinical prognosis, immune invasion, and drug sensitivity of THCA, but not only PTC.…”

Section: Discussionmentioning

confidence: 99%

Estrogen-related genes for thyroid cancer prognosis, immune infiltration, staging, and drug sensitivity

Zhang,

Zhou,

Gao

et al. 2023

BMC Cancer

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Background Thyroid cancer (THCA) has become increasingly common in recent decades, and women are three to four times more likely to develop it than men. Evidence shows that estrogen has a significant impact on THCA proliferation and growth. Nevertheless, the effects of estrogen-related genes (ERGs) on THCA stages, immunological infiltration, and treatment susceptibility have not been well explored. Methods Clinicopathological and transcriptome data of patients with THCA from the Gene Expression Omnibus (GEO) and The Cancer Genome Atlas (TCGA) were cleaned before consensus clustering. Differential expression analysis was performed on the genes expressed between THCA and paraneoplastic tissues in TCGA, and Wayne analysis was performed on the ERGs obtained from the Gene Set Enrichment Analysis MsigDB and differentially expressed genes (DEGs). Univariate Cox and least absolute shrinkage and selection operator (LASSO) analyses were used to identify the set of estrogen-related differentially expressed genes (ERDEGs) associated with progression-free intervals (PFI) and to establish a prediction model. Receiver operating characteristic curves were plotted to calculate the risk scores and PFI status to validate the predictive effect of the model. Enrichment analyses and immune infiltration analyses were performed to analyze DEGs between the high- and low-risk groups, and a nomogram plot was used in the risk model to predict the PFI of THCA. Results The expression of 120 ERDEGs differed significantly between the two groups (P < 0.05). Five (CD24, CAV1, TACC1, TIPARP, and HSD17B10) of the eight ERDEGs identified using univariate Cox and LASSO regression were validated via RT-qPCR and immunohistochemistry analysis of clinical tissue samples and were used for clinical staging and drug sensitivity analysis. Risk-DEGs were shown to be associated with immune modulation and tumor immune evasion, as well as defense systems, signal transduction, the tumor microenvironment, and immunoregulation. In 19 of the 28 immune cells, infiltration levels differed between the high- and low-risk groups. High-risk patients in the immunotherapy dataset had considerably shorter survival times than low-risk patients. Conclusion We identified and confirmed eight ERDEGs using a systematic analysis and screened sensitive drugs for ERDEGs. These results provide molecular evidence for the involvement of ERGs in controlling the immunological microenvironment and treatment response in THCA.

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Identification and validation of eight estrogen-related genes for predicting prognosis of papillary thyroid cancer

Cited by 2 publications

References 35 publications

The Tumor Microenvironment and the Estrogen Loop in Thyroid Cancer

The Tumor Microenvironment and the Estrogen Loop in Thyroid Cancer

Estrogen-related genes for thyroid cancer prognosis, immune infiltration, staging, and drug sensitivity

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