Identification and Validation of Compounds Targeting Leishmania major Leucyl-Aminopeptidase M17
Mirtha E. Aguado,
Sandra Carvalho,
Mario E. Valdés-Tresanco
et al.
Abstract:Leishmaniasis is a neglected tropical disease; there is currently no vaccine and treatment is reliant upon a handful of drugs suffering from multiple issues including toxicity and resistance. There is a critical need for development of new fitfor-purpose therapeutics, with reduced toxicity and targeting new mechanisms to overcome resistance. One enzyme meriting investigation as a potential drug target in Leishmania is M17 leucyl-aminopeptidase (LAP). Here, we aimed to chemically validate LAP as a drug target i… Show more
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