Identification and validation of a pyroptosis-related prognostic signature for thyroid cancer

Wu, Pu; Shi, Jinyuan; Sun, Wei; Zhang, Hao

doi:10.1186/s12935-021-02231-0

Cited by 26 publications

(20 citation statements)

References 48 publications

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“…In HCC, a recent study revealed a mechanism of action for sorafenib, eliciting macrophage pyroptosis that enhances NK-cell effector function and ultimately effective HCC cell killing [ 10 ]. Prognostic signatures based on PRGs were established for lung adenocarcinoma, ovarian cancer, and thyroid cancer [ 11 – 13 ]. However, the prognostic value of PRGs in HCC has not been studied extensively.…”

Section: Introductionmentioning

confidence: 99%

A pyroptosis-related gene signature predicts prognosis and immune microenvironment in hepatocellular carcinoma

Jin

Ping

et al. 2022

World J Surg Onc

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Background Hepatocellular carcinoma (HCC) is a highly malignant tumor with a very poor prognosis. Pyroptosis is an inflammatory form of cell death and plays an important role in cancer development. The prognostic value of pyroptosis-related genes (PRGs) in HCC has not been studied extensively. Methods Unsupervised consensus clustering analysis was performed to identify two subtypes based on the expression profiles of prognostic PRGs in the The Cancer Genome Atlas (TCGA) database, and the differences between the two subtypes were compared. A prognostic model based on four PRGs was established by further least absolute shrinkage and selection operator (LASSO) Cox regression analysis and multivariate Cox regression analysis. Results Two subtypes (clusters 1 and 2) were identified by consensus clustering based on prognostic PRGs in HCC. Survival outcomes, biological function, genomic alterations, immune cell infiltration, and immune checkpoint genes were compared between the subtypes. Cluster 2 had a worse survival outcome than cluster 1. Cluster 2 was enriched for hallmarks of cancer progression, TP53 mutation, tumor-promoting immune cells, and immune checkpoint genes, which may contribute to the poor prognosis. A prognostic risk signature that predicted the overall survival (OS) of patients was constructed and validated. Consequently, a risk score was calculated for each patient. Combined with the clinical characteristics, the risk score was found to be an independent prognostic factor for survival of HCC patients. Further analysis revealed that the risk score was closely associated with the levels of immune cell infiltration and the expression profiles of immune checkpoint genes. Conclusions Collectively, our study established a prognostic risk signature for HCC and revealed a significant correlation between pyroptosis and the HCC immune microenvironment.

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Section: Introductionmentioning

confidence: 99%

A pyroptosis-related gene signature predicts prognosis and immune microenvironment in hepatocellular carcinoma

Jin

Ping

et al. 2022

World J Surg Onc

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“…Our study has several advantages over previous studies on certain cancers. First, previous studies focused on the development and validation of prognostic models involving certain cancer types [32][33][34][35]. Our studies aimed to assess pyroptosis levels in cancer as a whole, and our model of pyroptosis levels is thus more universal.…”

Section: Discussionmentioning

confidence: 99%

Pan-cancer analyses of pyroptosis with functional implications for prognosis and immunotherapy in cancer

Liu

Shen

et al. 2022

J Transl Med

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Background Programmed cell death is an active and orderly form of cell death regulated by intracellular genes that plays an important role in the normal occurrence and development of the immune system, and pyroptosis has been found to be involved in tumorigenesis and development. However, compressive analysis and biological regulation of pyroptosis genes are lacking in cancers. Methods Using data from The Cancer Genome Atlas, we established a score level model to quantify the pyroptosis level in cancer. Multiomics bioinformatic analyses were performed to assess pyroptosis-related molecular features and the effect of pyroptosis on immunotherapy in cancer. Results In the present study, we performed a comprehensive analysis of pyroptosis and its regulator genes in cancers. Most pyroptosis genes were aberrantly expressed in different types of cancer, attributed to the CAN frequency and differences in DNA methylation levels. We established a pyroptosis level model and found that pyroptosis had dual roles across cancers, while the pyroptosis levels were different among multiple cancers and were significantly associated with clinical prognosis. The dual role of pyroptosis was also shown to affect immunotherapeutic efficacy in several cancers. Multiple pyroptosis genes showed close associations with drug sensitivity across cancers and may be considered therapeutic targets in cancer. Conclusions Our comprehensive analyses provide new insight into the functions of pyroptosis in the initiation, development, progression and treatment of cancers, suggesting corresponding prognostic and therapeutic utility.

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“…The model was determined by penalty parameter (λ) with ten-fold cross-validation following the minimum criteria. The risk score of each THCA patient was calculated by the following formula: Risk score = βA * Expression level of Gene A + βB * Expression level of Gene B + … + βN * Expression level of Gene N, (β: regression coe cient) 24 . Patients were separated into high-and low-risk group based on the median risk score.…”

Section: Construction and Validation Of The Immune-related Ernas Prog...mentioning

confidence: 99%

A novel immune-related eRNAs prognostic signature to predict the immunotherapy response for thyroid carcinoma

Shi

Wang

et al. 2022

Preprint

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Background The functional alterations of eRNAs have been reported to be correlated with tumorigenesis. However, the roles of eRNAs in thyroid cancer (THCA) remain still unclear. This study aimed to construct an immune-related eRNA prognostic signature that could effectively predict the survival and prognosis for THCA. Methods The Weighted Gene Co-Expression Network Analysis (WGCNA) was performed to identify THCA-specific immune-related hub genes and immune-related eRNAs were obtained using Pearson correlation analysis. Univariate and least absolute shrinkage and selection operator (LASSO) Cox regression were conducted to construct an immune-related eRNA prognostic signature in training cohort, and the predictive capability was verified in test cohort and entire cohort. Kaplan-Meier analysis, principal component analysis (PCA), receiver operating characteristic (ROC) curves, and nomogram were used to validate the risk signature. Furthermore, CIBERSORT, ESTIMATE and ssGSEA were analyzed to explore the tumor immune microenvironment (TIME) of the risk signature, and the response of potential immunotherapeutic were also discussed. Results A total of 125 immune-related eRNAs were obtained and 16 immune-related eRNAs were significantly correlated with overall survival (OS). A 9-immune-related eRNA prognostic signature was constructed, and the risk score was identified as an independent predictor. High-risk groups were associated with a poorer OS. Immune microenvironment analysis indicated that low risk score was correlated with higher immuneScore, high immune cell infiltration, and the better response of immunotherapy. Additionally, we also detected 9 immune-related eRNA expression levels in sixty-two matched tumorous and non-tumorous tissues using qRT-PCR analysis. Conclusion Our immune-related eRNA risk signature that was an independent prognostic factor was strongly correlated with the immune microenvironment and may be promising for the clinical prediction of prognosis and immunotherapeutic responses in THCA patients.

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Identification and validation of a pyroptosis-related prognostic signature for thyroid cancer

Cited by 26 publications

References 48 publications

A pyroptosis-related gene signature predicts prognosis and immune microenvironment in hepatocellular carcinoma

A pyroptosis-related gene signature predicts prognosis and immune microenvironment in hepatocellular carcinoma

Pan-cancer analyses of pyroptosis with functional implications for prognosis and immunotherapy in cancer

A novel immune-related eRNAs prognostic signature to predict the immunotherapy response for thyroid carcinoma

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