Identification and validation of a novel anoikis-related signature for predicting prognosis and immune landscape in ovarian serous cystadenocarcinoma

Zhu, Yuting; Wu, Shuang-Yue; Song, Yang; Ying, Jie; Liu, Tian; Hua, Xu; Zhang, Heping; Yao, Hui; Zhang, Weiyu; Jin, Qinqin; Yang, Yinting; Jiang, Xiya; Zhang, Nan; Yao, Shuochao; Zhou, Sheng; Guo, Chen

doi:10.1016/j.heliyon.2023.e18708

Heliyon

2023

DOI: 10.1016/j.heliyon.2023.e18708

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Identification and validation of a novel anoikis-related signature for predicting prognosis and immune landscape in ovarian serous cystadenocarcinoma

Yuting Zhu¹,

Shuang-Yue Wu²,

Yang Song³

et al.

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2024

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Anoikis in cell fate, physiopathology, and therapeutic interventions

Mei,

Jiang,

Tian

et al. 2024

MedComm

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The extracellular matrix (ECM) governs a wide spectrum of cellular fate processes, with a particular emphasis on anoikis, an integrin‐dependent form of cell death. Currently, anoikis is defined as an intrinsic apoptosis. In contrast to traditional apoptosis and necroptosis, integrin correlates ECM signaling with intracellular signaling cascades, describing the full process of anoikis. However, anoikis is frequently overlooked in physiological and pathological processes as well as traditional in vitro research models. In this review, we summarized the role of anoikis in physiological and pathological processes, spanning embryonic development, organ development, tissue repair, inflammatory responses, cardiovascular diseases, tumor metastasis, and so on. Similarly, in the realm of stem cell research focused on the functional evolution of cells, anoikis offers a potential solution to various challenges, including in vitro cell culture models, stem cell therapy, cell transplantation, and engineering applications, which are largely based on the regulation of cell fate by anoikis. More importantly, the regulatory mechanisms of anoikis based on molecular processes and ECM signaling will provide new strategies for therapeutic interventions (drug therapy and cell‐based therapy) in disease. In summary, this review provides a systematic elaboration of anoikis, thus shedding light on its future research.

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Anoikis in cell fate, physiopathology, and therapeutic interventions

Mei,

Jiang,

Tian

et al. 2024

MedComm

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Identification and validation of a novel anoikis-related signature for predicting prognosis and immune landscape in ovarian serous cystadenocarcinoma

Cited by 1 publication

References 45 publications

Anoikis in cell fate, physiopathology, and therapeutic interventions

Anoikis in cell fate, physiopathology, and therapeutic interventions

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