Identification and theoretical explanation of chemical composition against α-amylase in the n-hexane extract from Sargassum fusiforme

Yang, Jiao; Liu, Chang; Cai, Hengjiang; Gu, Dongyu; Ji, Zhenni; Guo, Xinfeng; Tian, Jing; Meng, Jing; Yang, Yi

doi:10.1016/j.algal.2019.101642

Cited by 10 publications

(2 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is used widely as a food and medicinal ingredient in Asian countries and is cultivated on a vast scale in coastal zones in Asia as an economic seaweed [ 22 , 23 , 24 ]. Previous reports have suggested that the polysaccharides from H. fusiforme possess various bioactivities such as antioxidant, anti-virus, anti-cancer, anti-inflammatory, and anti-diabetic activities [ 22 , 23 , 24 , 25 , 26 , 27 , 28 ]. In a previous study, we had isolated a fucoidan from H. fusiforme and found that it possessed strong antioxidant activity, which suggested its cosmeceutical potential of the fucoidan [ 29 ].…”

Section: Introductionmentioning

confidence: 99%

Anti-Photoaging and Anti-Melanogenesis Effects of Fucoidan Isolated from Hizikia fusiforme and Its Underlying Mechanisms

Wang

Kim

et al. 2020

Marine Drugs

View full text Add to dashboard Cite

Previous studies suggested that fucoidan with a molecular weight of 102.67 kDa, isolated from Hizikia fusiforme, possesses strong antioxidant activity. To explore the cosmeceutical potential of fucoidan, its anti-photoaging and anti-melanogenesis effects were evaluated in the present study. The anti-photoaging effect was investigated in ultraviolet (UV) B-irradiated human keratinocytes (HaCaT cells), where fucoidan effectively reduced the intracellular reactive oxygen species level and improved the viability of the UVB-irradiated cells without any cytotoxic effects. Moreover, fucoidan significantly decreased UVB-induced apoptosis in HaCaT cells by regulating the protein expression of Bax, Bcl-xL, PARP, and Caspase-3 in HaCaT cells in a concentration-dependent manner. The anti-melanogenesis effect of fucoidan was evaluated in B16F10 melanoma cells that had been stimulated with alpha-melanocyte-stimulating hormone (α-MSH), and fucoidan treatment remarkably inhibited melanin synthesis in α-MSH-stimulated B16F10 cells. Further studies indicated that fucoidan significantly suppressed the expression of tyrosinase and tyrosinase-related protein-1 and -2 (TRP-1 and-2) in B16F10 cells by down-regulating microphthalmia-associated transcription factor (MITF) through regulation of the ERK–MAPK (extracellular signal regulated kinase-mitogen activated protein kinase) pathway. Taken together, these results suggest that fucoidan isolated from H. fusiforme possesses strong anti-photoaging and anti-melanogenesis activities and can be used as an ingredient in the pharmaceutical and cosmeceutical industries.

show abstract

Section: Introductionmentioning

confidence: 99%

Anti-Photoaging and Anti-Melanogenesis Effects of Fucoidan Isolated from Hizikia fusiforme and Its Underlying Mechanisms

Wang

Kim

et al. 2020

Marine Drugs

View full text Add to dashboard Cite

show abstract

“…The ethanolic extracts of brown, green and red seaweeds were evaluated for their α-amylase inhibitory activity compared with those of a commercial inhibitor, acarbose. The inhibitory effects on α-amylase of the brown, green, and red ethanolic extracts and acarbose are shown in (Park & Han, 2012;Pak et al, 2015;Yang et al, 2019). S. thunbergi showed α-amylase inhibition effect (66.29%) at 5 mg/mL (Lee, 2010).…”

Section: Inhibition Of α-Amylasementioning

confidence: 99%

α-amylase and α-glucosidase inhibition effects of Korean edible brown, green, and red seaweed extracts

Ryu¹,

Lee²,

Yim³

et al. 2023

Fish Aquat Sci

View full text Add to dashboard Cite

The control of intestinal α-amylase and α-glucosidase is an effective therapeutic strategy for prevention of post-prandial hyperglycemia associated with diabetes mellitus. The objective of this study was to evaluate the anti-diabetes activities of Korean edible seaweed against α-amylase and α-glucosidase, two carbolytic enzymes involved in serum glucose regulation. Of the 41 species initially screened, Cladophora wrightiana var. minor, Eisenia bicyclis, Ecklonia cava, Ishige foliacea, and Ishige okamurae exhibited the strongest inhibitory activities from brown seaweeds. Asparagopsis taxiformis showed the strongest inhibitory effects from red seaweeds. The results of this study suggest that the crude brown seaweed extracts (C. wrightiana var. minor, E. bicyclis, E. cava, I. foliacea, and I. okamurae) and crude red seaweed extracts (A. taxiformis) may have beneficial effects suppressing the rise in postprandial hyperglycemia through the inhibition of α-amylase and α-glucosidase.

show abstract

Arsenic removal from the popular edible seaweed Sargassum fusiforme by sequential processing involving hot water, citric acid, and fermentation

Wang

Cui

et al. 2022

Chemosphere

View full text Add to dashboard Cite

Identification and theoretical explanation of chemical composition against α-amylase in the n-hexane extract from Sargassum fusiforme

Cited by 10 publications

References 29 publications

Anti-Photoaging and Anti-Melanogenesis Effects of Fucoidan Isolated from Hizikia fusiforme and Its Underlying Mechanisms

Anti-Photoaging and Anti-Melanogenesis Effects of Fucoidan Isolated from Hizikia fusiforme and Its Underlying Mechanisms

α-amylase and α-glucosidase inhibition effects of Korean edible brown, green, and red seaweed extracts

Arsenic removal from the popular edible seaweed Sargassum fusiforme by sequential processing involving hot water, citric acid, and fermentation

Contact Info

Product

Resources

About