Identification and targeting of microbial putrescine acetylation in bloodstream infections
Jared R. Mayers,
Jack Varon,
Ruixuan R. Zhou
et al.
Abstract:The growth of antimicrobial resistance (AMR) has highlighted an urgent need to identify bacterial pathogenic functions that may be targets for clinical intervention. Although severe bacterial infections profoundly alter host metabolism, prior studies have largely ignored alterations in microbial metabolism in this context. Performing metabolomics on patient and mouse plasma samples, we identify elevated levels of bacterially-derived N-acetylputrescine during gram-negative bloodstream infections (BSI), with hig… Show more
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