“…Surprisingly, these RNA binding-proteins recognize and bind to mRNA containing G4 motifs ( Ishiguro et al, 2021 ). For instance, ALS-linked intronic expansion of the human C9orf72 gene and potentially causative two long noncoding RNAs, NEAT1 (nuclear enriched abundant transcript 1) and MALAT1 (metastasis associated in lung adenocarcinoma transcript 1/NEAT2) contain abundant G4 motifs ( Grigg et al, 2014 ; Haeusler et al, 2014 ; Simko et al, 2020 ; Mou et al, 2022 ). More interestingly, these ALS-related proteins/RNAs constitute RNP granules or regulate the formation of RNP granules ( Tourrière et al, 2003 ; Fujii et al, 2005 ; Guil et al, 2006 ; Bosco et al, 2010 ; Molliex et al, 2015 ; Mensch et al, 2018 ; Ishiguro et al, 2021 ).…”