Identification and structure elucidation of a new degradation impurity in the multi-component tablets of amlodipine besylate

Development and validation of sensitive high‐performance liquid chromatography‐photodiode array method for determination of three sulfonated esters and N‐methyl‐O‐phenyldiamine dihydrochloride as potential genotoxic impurities in Amlodipine and Telmisartan fixed‐dose combination

“…Various methods have already been developed [12,[15][16][17][18][19][20][21][22][23][24][25][26][27][28][29] for the determinations of AMLO with various GTIs and have even achieved the detection level of 1 μg/ml and ∼20 ppb levels [24,25]. However, these reported analytical methods involved sophisticated LC-MS/MS techniques, which are normally not available in developing or upcoming pharmaceutical laboratories, Therefore, it was seeming essential to develop a sensitive, stability-indicating, accurate and robust HPLC-photodiode array (HPLC-PDA)based analytical method to quantify NMOPD, and selected alkyl benzene sulfonates in TELMI and AMLO that might be present in finished pharmaceutical preparations.…”

A Photoelectrochemical Sensor for Firstly the Detection of Amlodipine Besylate Based on an MnC4Pc Coated ZnO Composite Materials

“…If such prescription drugs are not used as required, they may cause electrolytes in the human body to flocculate, resulting in metabolic abnormalities, hyponatremia, hypokalemia, peripheral edema, and other side effects [6]. At present, the methods commonly used to detect the content of AB include reversed-phase ultrahigh performance liquid chromatography-mass spectrometry [7], liquid chromatography-tandem mass spectrometry [8], electrochemical [9], spectrophotometry [10,11], and fluorescence spectroscopy [12]. These analytical methods have their advantages, but they also face the problems of cumbersome experimental operation, timeconsuming, and expensive instruments [13].…”