Identification and structural elucidation of bioactive compounds from Scirpoides holoschoenus

Mittas, Domenic; Spitaler, Urban; Bertagnoll, Michaela; Oettl, Sabine; Gille, Elvira; Schwaiger, Stefan; Stuppner, Hermann

doi:10.1016/j.phytochem.2022.113241

Cited by 3 publications

(3 citation statements)

References 57 publications

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“…Moreover, the HPLC-UV chromatogram of the PRC fraction was almost identical to that of the DEE fraction of the methanolic extract of the rhizomes and roots of Scirpoides holoschoenus L., except for the lipophilic region at the end (Figure S5). In comparison to the published data [47], the HPLC-DAD and HPLC-ESI-MS analysis indicated the presence of two stilbene dimers: scirpusin A (21) and cassigarol E (26), five stilbene trimers: cyperusphenol D (20), passiflorinol A (22), cyperusphenol A (24), mesocyperusphenol A (25), and passiflorinol B (23), and one ferulic acid derivative: smiglaside C (27) in the PRC fraction of the methanolic extract of C. articulatus, in addition to 2R/2S dihydroluteolin (14), piceatannol (16), trans-scirpusin B (17), and cyperusphenol B (19), which were already isolated and tested. Finally, the PRC fraction, containing many potentially active stilbene oligomers, might be interesting for further investigations as well.…”

Section: Discussionmentioning

confidence: 84%

“…HPLC-UV chromatogram (205 nm) and peak assignment of the (A) PE fraction and (B) DEE fraction of the methanolic rhizomes and roots extract of Cyperus articulatus; for HPLC conditions, see Section 4.2 (General experimental methods). Due to a similar extract composition, the HPLC method for the DEE fraction of the methanolic rhizomes and roots extract, after DCM extraction of Scirpoides holoschoenus, was used for the DEE fraction of C. articulatus in (B)[47].…”

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confidence: 99%

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Bioassay-Guided Isolation of Anti-Inflammatory Constituents of the Subaerial Parts of Cyperus articulatus (Cyperaceae)

Mittas

Mawunu²,

Magliocca

et al. 2022

Molecules

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Based on data from a previous ethnobotanical study in northern Angola, phytochemical investigations into the methanolic rhizomes and roots extract of Cyperus articulatus, monitored by in vitro assays, resulted in the recovery of 12 sesquiterpenes, 3 stilbenes, 2 phenolic acids, 1 monoterpene, and 1 flavonoid. Among them, 14 compounds were isolated for the first time from this species. Their inhibitory potential against nitric oxide (NO) production, as well as inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) expression, was evaluated in LPS-treated J774A.1 murine macrophages. Especially, both stilbene dimer trans-scirpusin B and trimer cyperusphenol B showed promising inhibitory activity against the production of the inflammatory mediator, NO, in a concentration-dependent manner (10–1 µM). The obtained data are the first results confirming the anti-inflammatory potential of C. articulatus and support its indigenous use as a traditional remedy against inflammation-related disorders.

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Section: Discussionmentioning

confidence: 84%

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confidence: 99%

Bioassay-Guided Isolation of Anti-Inflammatory Constituents of the Subaerial Parts of Cyperus articulatus (Cyperaceae)

Mittas

Mawunu²,

Magliocca

et al. 2022

Molecules

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“…For the structural identification of crude extracts, the NMR spectra of the crude extracts were compared with the NMR spectra of compounds already identified in the database to determine the structures of the compounds [236]. For unknown compounds, the structure of natural products can be analyzed by one-and two-dimensional NMR spectroscopy combined with mass spectrometry [237][238][239].…”

Section: Nuclear Magnetic Resonance Spectroscopy (Nmr)mentioning

confidence: 99%

Extraction and Analysis of Chemical Compositions of Natural Products and Plants

Zhang,

Zhao,

Dai

et al. 2023

Separations

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There are many types of natural plants in nature that contain a variety of effective and complex chemical components. These constituents can be categorized as organic acids, volatile oils, coumarins, steroids, glycosides, alkaloids, carbohydrates, phytochromes, etc., all of which play important roles in the fields of pharmaceuticals, food, nutraceuticals, and cosmetics. The study of extraction and chemical composition analysis of natural products is important for the discovery of these active ingredients and their precursors. Therefore, the aim of this article is to review the status of research on the extraction, separation and purification, and structural identification of natural products, to provide a reference for the study of natural products.

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Analysis of herbal medicine among Bedouin of the Saint Catherine Protectorate (southern Sinai Peninsula) and its comparison to modern drug design

Ofir,

Lev,

Ron

et al. 2023

Sustainable Environment

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Identification and structural elucidation of bioactive compounds from Scirpoides holoschoenus

Cited by 3 publications

References 57 publications

Bioassay-Guided Isolation of Anti-Inflammatory Constituents of the Subaerial Parts of Cyperus articulatus (Cyperaceae)

Bioassay-Guided Isolation of Anti-Inflammatory Constituents of the Subaerial Parts of Cyperus articulatus (Cyperaceae)

Extraction and Analysis of Chemical Compositions of Natural Products and Plants

Analysis of herbal medicine among Bedouin of the Saint Catherine Protectorate (southern Sinai Peninsula) and its comparison to modern drug design

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