Identification and semi-quantitative determination of anti-oxidants in lubricants employing thin-layer chromatography-spray mass spectrometry

Kreisberger, Georg; Himmelsbach, Markus; Buchberger, Wolfgang; Klampfl, Christian W.

doi:10.1016/j.chroma.2015.01.048

Cited by 16 publications

(12 citation statements)

References 26 publications

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“…The TLC plates are cut to sharp point and an electrospray is induced from the tip. Aluminum backed TLC plates, which are easy to cut, have been the most widely used to date [65][66][67][68]. The TLC plate can be coupled directly to the MS in an online mode [65].…”

Section: Thin Layer Chromatography Platesmentioning

confidence: 99%

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Analysis of Biofluids by Paper Spray MS: Advances and Challenges

2016

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Paper spray mass spectrometry (MS) is part of a cohort of ambient ionization or direct analysis methods that seek to analyze complex samples without prior sample preparation. Extraction and electrospray ionization occur directly from the paper substrate upon which a dried matrix spot is stored. Paper spray MS is capable of detecting drugs directly from dried blood, plasma, and urine spots at the low ng/mL to pg/mL levels without sample preparation. No front end separation is performed, so tandem mass spectrometry (MS/MS) or high resolution MS is required. Here, we discuss paper spray methodology, give a comprehensive literature review of the use of paper spray MS for bioanalysis, discuss technological advancements and variations on this technique, and discuss some of its limitations. _________________________________________________________________________________ AbstractPaper spray mass spectrometry (MS) is part of a cohort of ambient ionization or direct analysis methods that seek to analyze complex samples without prior sample preparation. Extraction and electrospray ionization occur directly from the paper substrate upon which a dried matrix spot is stored. Paper spray MS is capable of detecting drugs directly from dried blood, plasma, and urine spots at the low ng/mL to pg/mL levels without sample preparation. No front end separation is performed, so tandem mass spectrometry (MS/MS) or high resolution MS is required. Here, we discuss paper spray methodology, give a comprehensive literature review of the use of paper spray MS for bioanalysis, discuss technological advancements and variations on this technique, and discuss some of its limitations.

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Section: Thin Layer Chromatography Platesmentioning

confidence: 99%

“…Another option is to perform the TLC separation offline and cut the bands out in a triangle shape. Extraction and ionization can then be done directly from the removed portion of the TLC plate [68].…”

Section: Thin Layer Chromatography Platesmentioning

confidence: 99%

Analysis of Biofluids by Paper Spray MS: Advances and Challenges

2016

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“…续地洗脱分析物 [92] . 最近发展的TLC电喷雾电离技术, TLC板上预分离的样品点剪切成三角形的小片再加试剂提取样品并产生喷雾电离 [93,94] . 施加的试剂作为洗脱液和喷雾试剂, 样品逐个洗脱和喷出进入质谱检测 [86] , 如图2(c)所示.…”

Section: 早期的研究Tlc板通过板后开槽加入流动相可以持unclassified

Principles and applications of solid-substrate electrospray ionization mass spectrometry

Yao

2017

Sci. Sin.-Chim

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Direct analysis of raw samples is one of the important trends for mass spectrometry. Solid-substrate electrospray ionization mass spectrometry (solid-substrate ESI-MS) uses solid substrates (e.g., metal materials, porous materials) for sample loading and ionization, allows direct analysis of various forms of samples (e.g., liquid samples, viscous samples, solid samples and biological tissue), and shows analytical features that are different from conventional capillary-based ESI-MS. In recent years, solid-substrate ESI-MS has attracted more and more attention, and has been widely applied for direct sample analysis in biological, chemical, pharmaceutical and food studies. In this review, the principles and applications of typical solid-substrate ESI-MS techniques were highlighted, and the roles of solid substrates and solvents as well as the future development of solid-substrate ESI-MS were discussed.

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“…Coupling of TLC with MS has attracted much attention [20,21], and various ionization methods, including fast atom bombardment (FAB) [22,23], matrixassisted laser desorption/ionization (MALDI) [24] ionization methods such as liquid extraction junction [25][26][27], desorption electrospray ionization (DESI) [28,29], direct analysis in real time (DART) [30][31][32], easy ambient sonic-spray ionization (EASI) [33] and electrospray laser desorption ionization (ELDI) [34], have been employed for the coupling. In addition, direct coupling of TLC with ESI, in which separated sample spots were cut out for directly ESI or samples were separated online and then directly sprayed out, was also demonstrated [35][36][37]. However, the major purposes of these coupling studies were to facilitate identification of the separated TLC spots by MS or online separation and detection of compounds in simple mixtures.…”

Section: Introductionmentioning

confidence: 98%

Thin layer chromatography coupled with electrospray ionization mass spectrometry for direct analysis of raw samples

Xin

et al. 2015

Journal of Chromatography A

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Identification and semi-quantitative determination of anti-oxidants in lubricants employing thin-layer chromatography-spray mass spectrometry

Cited by 16 publications

References 26 publications

Analysis of Biofluids by Paper Spray MS: Advances and Challenges

Analysis of Biofluids by Paper Spray MS: Advances and Challenges

Principles and applications of solid-substrate electrospray ionization mass spectrometry

Thin layer chromatography coupled with electrospray ionization mass spectrometry for direct analysis of raw samples

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