Identification and quantitative determination of fenozan acid in biological objects by chromatomass spectrometry

Прокопов, А. А.; Berlyand, A. S.; Veselovskaya, N. V.; Ufimtseva, E. V.; Белова, М. В.; Shukil, L. V.

doi:10.1007/bf02524640

Cited by 3 publications

(8 citation statements)

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“…The experiments with intravenous administration were performed using FX injections. The drug was extracted from the blood plasma in an acid medium (i.e., in the form of FZA) and analyzed by GC-MS [2]. Data on the time variation of the average FZA concentration in the blood plasma of rabbits upon intravenous administration are presented in Fig.…”

Section: Resultsmentioning

confidence: 99%

“…Since FZA is insoluble in water, it was introduced per os in a dose of 100 mg/kg in the form of a solution with Tween-80. The drug was extracted from the blood plasma and analyzed as described in [2]. Experimental data on the dynamics of the average FZA concentration in the blood plasma of rabbits upon peroral administration are presented in Fig.…”

Section: Resultsmentioning

confidence: 99%

“…The blood samples for analyses were taken from the ear edge vein at certain time intervals (2,5,15,30, and 45 min and 1, 2, 4, 8, 16, and 24 h). The number of animals in each test group was n = 5.…”

Section: Experimental Partmentioning

confidence: 99%

“…The number of animals in each test group was n = 5. The drug concentration in the blood was determined using gas chromatography with mass-spectrometric analysis (GC-MS) as described previously [2]. The experimental data were automatically processed and the pharmacokinetic parameters were determined on a computer using the automated system of programs for individual dos-ing (ASPID) program package specially developed for simulation of the pharmacokinetic processes [3].…”

Section: Experimental Partmentioning

confidence: 99%

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Experimental pharmacokinetics of fenozan acid and fenoxan in rabbits

et al. 2006

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The experimental pharmacokinetics of the new antioxidant preparations -fenozan acid and fenoxan (potassium salt of fenozan acid) -were studied in rabbits by monitoring the concentration profiles of the drugs in the blood plasma. Upon peroral administration in a single dose of 100 mg/kg, both fenozan acid and fenoxan are rapidly absorbed into the blood, their maximum concentrations peaking within 12 min after administration. The dynamics of the fenozan acid concentration in the blood plasma upon peroral administration was described by a one-compartment pharmacokinetic model, and that upon the intravenous injection, by a two-compartment model. The pharmacokinetic parameters characterizing the distribution and elimination of fenozan acid and fenoxan were close for both peroral administration and intravenous injections. Fenozan acid was slowly eliminated from the rabbit organism, the mean retention times being 11.3 and 11.8 h; the half-elimination times, 8.28 h and 7.68 h; and the stationary distribution volume, 20.8 and 37.5 liter/kg (i.v. versus p.o., respectively), which is indicative of intracell penetration of the drug and its trapping by organs and tissues. The relatively low value (F = 57.8%) of the bioavailability of fenozan acid upon peroral administration is related to a presystemic metabolism of this drug. 5 0091-150X/06/4001-0005

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Experimental Partmentioning

confidence: 99%

Section: Experimental Partmentioning

confidence: 99%

See 2 more Smart Citations

Experimental pharmacokinetics of fenozan acid and fenoxan in rabbits

et al. 2006

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show abstract

“…The number of animals in each test group was n = 5. The drug concentration in the blood was determined using gas chromatography with mass-spectrometric analysis (GC-MS) as described previously [2]. The experimental data were automatically processed and the pharmacokinetic parameters were determined on a computer using an automated system of programs for individual dosing (ASPID) program package specially developed for simulation of the pharmacokinetic processes [3].…”

Section: Experimental Partmentioning

confidence: 99%

Studying the bioavailability of fenozan acid in various medicinal forms

2006

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The bioavailability of fenozan acid as an antioxidant from tablets and rectal suppositories was studied in vitro and in vivo (rabbits). The complete release of fenozan acid from tablets in vitro takes 45 min, while 75% of the drug content is released from tablets within 21 min. The absolute bioavailability of fenozan acid from tablets and rectal suppositories in vivo amounts to 46.8 and 51.4%, respectively.

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Studying phenozan acid metabolism in rabbits

2006

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The metabolism of a new antioxidant agent -phenozan acid -was studied in rabbits. The main directions of this process are (i) oxidation of benzene ring with the formation of 2,6-di-tert-butyl-p-benzoquinone and (ii) dehydration of the propionic acid fragment with the formation of 4-hydroxy-3,5-di-tert-butylphenylacrylic acid methyl ester. The structures of metabolites were established by computer-aided gas chromatography/mass spectrometry and confirmed by direct synthesis. 61 0091-150X/06/4002-0061

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Identification and quantitative determination of fenozan acid in biological objects by chromatomass spectrometry

Cited by 3 publications

References 1 publication

Experimental pharmacokinetics of fenozan acid and fenoxan in rabbits

Experimental pharmacokinetics of fenozan acid and fenoxan in rabbits

Studying the bioavailability of fenozan acid in various medicinal forms

Studying phenozan acid metabolism in rabbits

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