Identification and quantitative determination of clonidine by HPLC method

Mamina, O.; Kabachny, Volodimir

doi:10.15587/2519-4852.2020.215101

Cited by 2 publications

(1 citation statement)

References 11 publications

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“…Identification and quantification of clonidine hydrochloride by the integrated HPLC method makes it possible to obtain reliable and reproducible research results. The HPLC method can be recommended for application in the practice of forensic bureaus, toxicology centers, clinical laboratories for drug studies on biological objects [21]. A high-performance liquid chromatography (HPLC) method has been developed and validated for the simultaneous determination of clonidine HCl with chlorthalidone in the raw material for tablet formulations.…”

Section: High-performance Liquid Chromatography (Hplc) Analysismentioning

confidence: 99%

Overview of the Determination of Clonidine Levels in Pharmaceutical Preparations

Safitri¹,

Rasyid²,

Andayani³

et al. 2021

IJPSM

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Clonidine is an α2-central agonist class of drugs widely used to treat cardiovascular diseases such as hypertension, heart attacks and help prevent strokes. The quality and safety of a drug preparation can be proven by testing the drug's quality assurance. In drug quality assurance, it is necessary to determine drug levels. Therefore, it is essential to look at the determination of clonidine levels in raw materials, mixtures, and pharmaceutical preparations. It is collecting data in this review article through trusted sites such as Google Scholar with the search keywords "clonidine hydrochloride," "clonidine analysis in pharmaceutical preparations" with a span of the last ten years (2010-2020). This review article aims to provide an overview of the various analytical techniques used to determine clonidine both in single substance form and in the pharmaceutical dosage form. Several analytical methods, such as UV-Visible spectrophotometry, potentiometry, high-performance liquid chromatography (HPLC), and high-performance thin-layer chromatography (HPTLC), have been reported to determine clonidine in the form of raw materials, mixtures, and pharmaceutical preparations. Overall, the determination of clonidine levels has been carried out by various analytical methods, including spectrophotometry, potentiometry, high-performance liquid chromatography (HPLC), and high-performance thin-layer chromatography (HPTLC). Analysis with the HPLC technique is widely used in research because it can detect samples with the lowest concentration. The HPLC-MS method has unique advantages and sensitivity in the analysis of clonidine in pharmaceutical preparations.

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Section: High-performance Liquid Chromatography (Hplc) Analysismentioning

confidence: 99%

Overview of the Determination of Clonidine Levels in Pharmaceutical Preparations

Safitri¹,

Rasyid²,

Andayani³

et al. 2021

IJPSM

View full text Add to dashboard Cite

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Quantification of ADHD medication in biological fluids of pregnant and breastfeeding women with liquid chromatography: a comprehensive review

De Hondt,

Cosemans,

Plusquin

et al. 2024

Front. Public Health

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Attention Deficit/Hyperactivity Disorder (ADHD) is a neurodevelopmental disorder that has long been considered a concern only in the pediatric population. However, symptoms often sustain into adulthood and may require medication. For women with ADHD, this also means dealing with the disorder during the reproductive period. Medication safety during pregnancy and breastfeeding is a critical concern, and the potential transfer of ADHD medication to infants remains a topic of scientific interest. The quantification of ADHD medications in both maternal blood and breast milk are vital for understanding their pharmacokinetics and potential exposure risks for (nursing) infants. This review aims (1) to compile and critically assess existing research on the transfer of ADHD medications into breast milk and the potential implications for nursing infants and (2) to provide a comprehensive overview and discussion of the literature regarding the quantification of methylphenidate, amphetamine, atomoxetine, viloxazine, guanfacine, clonidine and bupropion in the blood, urine, oral fluid, and breast milk with liquid chromatography. A literature search was conducted using PubMed, Scopus, and Web of Science, to identify relevant articles published from January 2014 up to December 2023. We illustrate the lack of methods to simultaneously monitor multiple ADHD medications as well as the lack of developed methods for breast milk. Finally, we highlight the need for continued research to refine our understanding of medication transfer into breast milk and potential risks, and to develop clinical guidelines to support mothers with ADHD in making informed choices regarding medication use during pregnancy and lactation.

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Identification and quantitative determination of clonidine by HPLC method

Cited by 2 publications

References 11 publications

Overview of the Determination of Clonidine Levels in Pharmaceutical Preparations

Overview of the Determination of Clonidine Levels in Pharmaceutical Preparations

Quantification of ADHD medication in biological fluids of pregnant and breastfeeding women with liquid chromatography: a comprehensive review

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