Identification and quantification of seven volatile n-nitrosamines in cosmetics using gas chromatography/chemical ionization–mass spectrometry coupled with head space-solid phase microextraction

Choi, Nam-Sup; Kim, Yong Pyo; Ji, Won Hyun; Hwang, Gwi Seo; Ahn, Yun Gyong

doi:10.1016/j.talanta.2015.10.045

Cited by 45 publications

(15 citation statements)

References 11 publications

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“…By minimizing the headspace volume, the amount of analytes adsorbed onto the fiber in the gas phase can be maximized (Yang and Peppard 1994). The setting on the manual SPME is described in more detail in our previous study (Choi et al 2016). The GC oven temperature was maintained at 40°C for 2 min and then reached to 320 at 10°C per min for DB-5MS and to limited temperature, 240°C for DB-WAX column.…”

Section: Instrumentationmentioning

confidence: 99%

Determination of volatile alkylpyrazines in microbial samples using gas chromatography-mass spectrometry coupled with head space-solid phase microextraction

et al. 2016

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Background: Determination of volatile alkylpyrazines (VAPs) in microbial samples is needed for the understanding of microbial metabolism. An analytical method for screening and quantification of six volatile alkylpyrazines was developed and successfully applied to the real microbial samples. Methods: Headspace-solid phase microextraction (HS-SPME) which is a simple extraction simultaneously carrying out clean-up and pre-concentration of VAPs in microbial samples was adopted. GC-TOF/MS with CombiPal SPME autosampler was used for fast screening of microbial samples and the optimization of HS-SPME condition. Separation and quantification of six VAPs that have the potential to be detected in microbial samples using quadrupole GC/MS in chemical ionization (CI) mode were carried out. Results: The optimal extraction conditions for HS-SPME at 50°C and 50 min were investigated. To eliminate matrix effects, DB-WAX column was more appropriate to separate each alkylpyrazines from the interferences than DB-5MS column. Chemical ionization provided enhanced confirmation from adduct ions ([M + 29] + and [M + 41] + ) of methane reagent gas as well as increasing signal intensity of molecular ions for quantitative analysis. Linear calibration curves of six alkylpyrazines were obtained within a range between 1 and 50 ng/g. Conclusions: This proposed method was successfully applied to the microbial samples. 2-Methylpyrazine and 2,5-dimethylpyrazine were determined in the level of 6.0~34.0 ng/g.

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Section: Instrumentationmentioning

confidence: 99%

Determination of volatile alkylpyrazines in microbial samples using gas chromatography-mass spectrometry coupled with head space-solid phase microextraction

et al. 2016

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“…Only few works regarding the determination of other N‐ nitrosamines in cosmetic products have been published, which are based on chromatographic techniques, such as GC–TEA , GC–MS , GC–MS/MS , LC–TEA , LC–UV–Vis , and LC–MS/MS .…”

Section: Introductionmentioning

confidence: 99%

“…Regarding the extraction techniques focused on the enrichment of N‐ nitrosamines, solid‐phase techniques are the most commonly used, such as SPE , dispersive solid‐phase extraction , and SPME , and only few published works make use of liquid‐based extraction techniques . Among them, dispersive liquid–liquid microextraction (DLLME) is a very popular liquid‐based microextraction technique for nonpolar compounds , but it is not useful for polar compounds.…”

Section: Introductionmentioning

confidence: 99%

Determination of N‐nitrosamines in cosmetic products by vortex‐assisted reversed‐phase dispersive liquid–liquid microextraction and liquid chromatography with mass spectrometry

Miralles

Chisvert

Salvador

2018

J of Separation Science

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A new analytical method for the simultaneous determination of trace levels of seven prohibited N-nitrosamines (N-nitrosodimethylamine, N-nitrosoethylmethylamine, N-nitrosopyrrolidine, N-nitrosodiethylamine, N-nitrosopiperidine, N-nitrosomorpholine, and N-nitrosodiethanolamine) in cosmetic products has been developed. The method is based on vortex-assisted reversed-phase dispersive liquid-liquid microextraction, which allows the extraction of highly polar compounds, followed by liquid chromatography with mass spectrometry. The variables involved in the extraction process were studied to obtain the highest enrichment factor. Under the selected conditions, 75 μL of water as extraction solvent was added to 5 mL of n-hexane sample solution and assisted by vortex mixing during 30 s to form the cloudy solution. The method was successfully validated showing good linearity (0.5-50 ng/mL), enrichment factors up to 65 depending on the target compound, limits of detection values of 1.8-50 ng/g, and good repeatability (RSD < 9.8%). Finally, the proposed method was applied to different cosmetic samples. Quantitative relative recovery values (80-113%) were obtained, thus showing that matrix effects were negligible. The achieved analytical features of the proposed method, besides of its simplicity and affordability, make it useful to perform the quality control of cosmetic products to ensure the safety of consumers.

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“…Solid-phase micro-extraction (SPME) coupled with ambient MS has been developed to directly detect complex samples with high sensitivity and low matrix interference. [41][42][43][44] To date, SPME has been successfully coupled to several ambient ionization techniques, such as DESI, 45 DART, [46][47][48] LTP, 49,50 and DCBI. 23,24 In addition, direct ionization of SPME bers, 51 a SPME probe coupled with nanoelectrospray ionization (nanoESI), [52][53][54] coated blade spray (CBS), [55][56][57] and surface-coated wooden-tip electrospray ionization (SCWT-ESI) 58,59 have been explored as novel strategies for rapid extraction of trace analytes for direct MS analysis of complex samples.…”

Section: Introductionmentioning

confidence: 99%

Rapid and sensitive detection of trace malachite green and its metabolite in aquatic products using molecularly imprinted polymer-coated wooden-tip electrospray ionization mass spectrometry

Huang

et al. 2017

RSC Adv.

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Identification and quantification of seven volatile n-nitrosamines in cosmetics using gas chromatography/chemical ionization–mass spectrometry coupled with head space-solid phase microextraction

Cited by 45 publications

References 11 publications

Determination of volatile alkylpyrazines in microbial samples using gas chromatography-mass spectrometry coupled with head space-solid phase microextraction

Determination of volatile alkylpyrazines in microbial samples using gas chromatography-mass spectrometry coupled with head space-solid phase microextraction

Determination of N‐nitrosamines in cosmetic products by vortex‐assisted reversed‐phase dispersive liquid–liquid microextraction and liquid chromatography with mass spectrometry

Rapid and sensitive detection of trace malachite green and its metabolite in aquatic products using molecularly imprinted polymer-coated wooden-tip electrospray ionization mass spectrometry

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