Identification and Quantification of 5-Methylcytosine and 5-Hydroxymethylcytosine on Random DNA Sequences by a Nanoconfined Electrochemiluminescence Platform
Abstract:5-Methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)
are two
of the most abundant epigenetic marks in mammalian genomes, and it
has been proven that these dual epigenetic marks give a more accurate
prediction of recurrence and survival in cancer than the individual
mark. However, due to the similar structure and low expression of
5mC and 5hmC, it is challenging to distinguish and quantify the two
methylation modifications. Herein, we employed the ten-eleven translocation
family dioxygenases (TET) to conve… Show more
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