Identification and physiological evaluation of the components from Citrus fruits as potential drugs for anti-corpulence and anticancer

Hirata, Toshifumi; Fujii, Masayuki; Akita, Kenji; Yanaka, Noriyuki; Ogawa, Kokichi; Kuroyanagi, Masanori; Hongo, Daiki

doi:10.1016/j.bmc.2008.11.039

Cited by 73 publications

(44 citation statements)

References 17 publications

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“…Although overexpression of NIK is inhibited by PMF and was long believed to be the most potent activator of IKK (Malinin et al, 1997;Régnier et experiments, however, question its involvement in IKK activation by TNF (Smith et al, 2001;Yin et al, 2001). Numerous hydroxylated polymethoxyflavones have been isolated primarily from orange juice, citrus peel, and dried tangerine peels (Takanaga et al, 2000;Hirata et al, 2009;Sun et al, 2009;Xiao et al, 2009;Zheng et al, 2009;Dong et al, 2010), including nobiletin, tangeretin, artemetin (Ahmed et al, 1988;Sertié et al, 1990), and sinensetin (Choi et al, 2002). Besides citrus, PMF analogs have also been identified from the spice thyme and estragon (Watanabe et al, 2005).…”

Section: Discussionmentioning

confidence: 99%

RETRACTION: A Novel Pentamethoxyflavone Down-Regulates Tumor Cell Survival and Proliferative and Angiogenic Gene Products through Inhibition of IκB Kinase Activation and Sensitizes Tumor Cells to Apoptosis by Cytokines and Chemotherapeutic Agents

et al. 2010

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Most anticancer drugs have their origin in traditional medicinal plants. We describe here a flavone, 5,3Ј-dihydroxy-3,6,7,8,4Ј-pentamethoxyflavone (PMF), from the leaves of the Thai plant Gardenia obtusifolia, that has anti-inflammatory and anticancer potential. Because the nuclear factor-B (NF-B) pathway is linked to inflammation and tumorigenesis, we investigated the effect of PMF on this pathway. We found that PMF suppressed NF-B activation induced by inflammatory agents, tumor promoters, and carcinogens. This suppression was not specific to the cell type. Although PMF did not directly modify the ability of NF-〉 proteins to bind to DNA, it inhibited IB␣ (inhibitory subunit of NF-B) kinase, leading to suppression of phosphorylation and degradation of IB␣, and suppressed consequent p65 nuclear translocation, thus abrogating NF-B-dependent reporter gene expression.Suppression of the NF-B cell signaling pathway by the flavone led to the inhibition of expression of NF-B-regulated gene products that mediate inflammation (cyclooxygenase-2), survival (XIAP, survivin, Bcl-xL, and cFLIP), proliferation (cyclin D1), invasion (matrix metalloproteinase-9), and angiogenesis (vascular endothelial growth factor). Suppression of antiapoptotic gene products by PMF correlated with the enhancement of apoptosis induced by tumor necrosis factor-␣ and the chemotherapeutic agents cisplatin, paclitaxel, and 5-flurouracil. Overall, our results indicate that PMF suppresses the activation of NF-B and NF-B-regulated gene expression, leading to the enhancement of apoptosis. This is the first report to demonstrate that this novel flavone has anti-inflammatory and anticancer effects by targeting the IKK complex.

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Section: Discussionmentioning

confidence: 99%

RETRACTION: A Novel Pentamethoxyflavone Down-Regulates Tumor Cell Survival and Proliferative and Angiogenic Gene Products through Inhibition of IκB Kinase Activation and Sensitizes Tumor Cells to Apoptosis by Cytokines and Chemotherapeutic Agents

et al. 2010

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“…A screening of 78 citrus species showed inhibitory effects of the Epstein-Barr virus antigen (EBV-EA) activation, indicating that citrus phytochemicals may inhibit susceptibility factors involved in the events leading to the development of cancer (Iwase et al 1999 ) . Hirata and his group, in a study conducted on citrus peels, isolated polymethoxy fl avones and coumarin derivatives with anti-corpulence activities and the ability to inhibit the proliferation of human colon cancer HT-29 cells (Hirata et al 2009 ) .…”

Section: Cancer Chemoprevention Potentialmentioning

confidence: 98%

Phytophenolic Nutrients in Citrus: Biochemical and Molecular Evidence

Bahorun

Ramful-Baboolall

Neergheen-Bhujun

et al. 2012

Advances in Citrus Nutrition

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Natural products as disease remedies have a history of near 5,000 years (India, China and Greece), and even today, in this advanced technological age, a revival of interest is being witnessed in the use of natural or plant-based therapeutic agents for the treatment of several pathological conditions. Citrus fruits have been utilised as a traditional medicine in India, China, Korea and Japan, and many studies have highlighted the various biological properties of their phytophenolics which are suggested to be responsible for the prevention of degenerative diseases such as diabetes and cancer. With the background of comprehensive studies conducted on Mauritian citrus fruits, this chapter reviews some of the literature data on the phytophenolic contents, vitamin C composition and antioxidant functions of citrus extracts and emphasises on their potential applications in nutrition management programmes for diabetes and cancer chemoprevention.

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“…Amongst them, polymethoxyflavones (PMFs) show chemopreventive potential in antimutagenic and antitumor properties (Li, Lambros, Wang, Goodnow, & Ho, 2007;Li et al, 2009aLi et al, , 2009bWalle, 2007). Various Citrus species present different composition of PMFs (Green, Wheatley, Osagie, St. A. Morrison, & Asemota, 2006;Hirata et al, 2009;Li, Pan, et al, 2007;Mizuno, Iinuma, Ohara, Tanaka, & Iwamasa, 1991). Ponkan, the fruit of Citrus reticulata Blanco cv.…”

Section: Introductionmentioning

confidence: 98%

The methoxyflavones in Citrus reticulata Blanco cv. ponkan and their antiproliferative activity against cancer cells

Chen

2010

Food Chemistry

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Identification and physiological evaluation of the components from Citrus fruits as potential drugs for anti-corpulence and anticancer

Cited by 73 publications

References 17 publications

RETRACTION: A Novel Pentamethoxyflavone Down-Regulates Tumor Cell Survival and Proliferative and Angiogenic Gene Products through Inhibition of IκB Kinase Activation and Sensitizes Tumor Cells to Apoptosis by Cytokines and Chemotherapeutic Agents

RETRACTION: A Novel Pentamethoxyflavone Down-Regulates Tumor Cell Survival and Proliferative and Angiogenic Gene Products through Inhibition of IκB Kinase Activation and Sensitizes Tumor Cells to Apoptosis by Cytokines and Chemotherapeutic Agents

Phytophenolic Nutrients in Citrus: Biochemical and Molecular Evidence

The methoxyflavones in Citrus reticulata Blanco cv. ponkan and their antiproliferative activity against cancer cells

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