Identification and Pharmacokinetics of Multiple Potential Bioactive Constituents after Oral Administration of Radix Astragali on Cyclophosphamide-Induced Immunosuppression  in Balb/c Mice

Liu, Menghua; Li, Panlin; Zeng, Xuan; Wu, Haiwei; Su, Weiwei; He, Jingyu

doi:10.3390/ijms16035047

Cited by 49 publications

(45 citation statements)

References 37 publications

(43 reference statements)

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“…Astragalus membranaceus has a complex chemical profile. Its major active constituents include saponins, flavonoids and polysaccharides (Liu et al, 2015;Ma, Shi, Duan, Dong, & Tsim, 2002). Other components found in the herb include phytosterols, amino acids and trace elements (Auyeung et al, 2016;Ma et al, 2002;Wang et al, 2019).…”

Section: Astragalus Membranaceus Bunge Is a Flowering Plant In The Famentioning

confidence: 99%

Plants in the management of male infertility

Onuah

Singh

2020

Andrologia

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This review attempts to collate existing data and provide the perspectives for future studies on the effects of plants on the male gonads. For many of these medicinal plants such as Lepidium meyenii, Rupus coreanus, Tribulus terrestres, Panax ginseng, Petasites japonicas, Apium graveolens, Eurycoma longifólia, Pedalium murex, Corchorus depressus, Mucuna pruriens, Astragalus membranaceus, Nigella sativa, Crataegus monogyna, Fagara tessmannii, Phaleria macrocarpa, Anacyclus pyrethrum, Cynomorium songaricum and Morinda officinalis, the mechanism of actions of their active principles and crude extracts has been shown in both laboratory animals, in vitro, and human studies, and includes their antioxidant, anti‐inflammatory, spermatogenesis‐inducing, aphrodisiac, smooth muscle relaxing and androgenic properties. Several active chemical leads including glucosinolates, anthocyanins, protodioscin, ginsenosides, sesquiterpenes, phyto‐oestrogens, quassinoids, diosgenin, thymoquinone, proanthocyanidins and bajijiasu isolated from these plants are known to have target effects on the testis, but efforts have been limited in their application at the clinical level. There still appear to be many more extracts of medicinal plants that have not been characterised to determine the phytochemicals unique to them that have target effects on the gonads. Further, collaborative efforts at isolating pro‐drug candidates from medicinal plants for studies at the molecular, cellular and clinical level towards elucidating their mechanisms of action on the testes are therefore warranted in the light of the current male fertility crisis.

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Section: Astragalus Membranaceus Bunge Is a Flowering Plant In The Famentioning

confidence: 99%

Plants in the management of male infertility

Onuah

Singh

2020

Andrologia

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“…The concentrations of the bioactive compounds, ononin, isoliquiritin, formononetin, calycosin, and liquiritin, reached maximum levels quickly, whereas isoliquiritigenin reached maximum levels at a later time of 4 h after oral administration ( Figure a ). These metabolites were eliminated from plasma at 12 h postdose, as in previous studies . Figure b shows the concentration profiles of several representative secondary metabolites of the absorbed HQD metabolite.…”

Section: Resultsmentioning

confidence: 90%

“…These metabolites were eliminated from plasma at 12 h postdose, as in previous studies. 17 Figure 3b shows the concentration profiles of several representative secondary metabolites of the absorbed HQD metabolite. Glycyrrhetinic acid, cycloastragenol, and formononetin glucuronide reached maximum levels in plasma 8 h postdose.…”

Section: Identification Of Absorbed Hqd Compounds and The Secondary Mmentioning

confidence: 99%

Poly‐pharmacokinetic Study of a Multicomponent Herbal Medicine in Healthy Chinese Volunteers

Xie

Wang

Zhang

et al. 2017

Clin Pharma and Therapeutics

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The advent of mass spectrometry-based analytical technologies coupled with multivariate statistical methods offer tremendous new opportunities for understanding the pharmacokinetics (PKs) of multicomponent herbal medicines (HMs). We recently proposed a poly-PK strategy to characterize the concentration-time profile and the metabolic response profile of multicomponent HMs using an integrated phytochemical and metabolomics approach. Here, we provided the first example of the poly-PK strategy, in which we simultaneously characterized the PK as well as the metabolic response profiles of a Chinese HM, Huangqi decoction (HQD, consisting of Radix Astragali and Radix Glycyrrhizae), in healthy Chinese volunteers. Using the poly-PK approach, we identified 56 HQD-derived compounds and 292 biotransformed HQD metabolites in human plasma. Additionally, we acquired the concentration-time profiles of these plasma HQD metabolites and correlated them with a plasma metabolomics profile consisting of 166 human endogenous metabolites that were significantly altered in response to HQD intervention.

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“…3). Their structures were characterized by UV, MS, and 1 H NMR spectroscopy (Supporting Information) [33][34][35][36]. Two typical absorption peaks of flavonoids (near 255 and 355 nm) were observed in the UV spectra of compounds 2, 3, and 4.…”

Section: Structural Identificationmentioning

confidence: 99%

Target-guided isolation of polar antioxidants fromAbelmoschus esculentus(L). Moench by high-speed counter-current chromatography method coupled with wavelength switching and extrusion elution mode

Wang

Liu

et al. 2016

J. Sep. Science

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An off-line two-dimensional high-speed counter-current chromatography strategy combined with the wavelength switching technique and extrusion elution mode was successfully developed and applied to the isolation of polar antioxidants from Abelmoschus esculentus (L).Moench. Target-guided by the result of 2,2-diphenyl-1-picrylhydrazyl screening assay, four antioxidants were obtained with purities over 90% through orthogonal high-speed counter-current chromatography separation. UV spectroscopy, mass spectrometry and H NMR spectroscopy were employed to identify their structures, which were assigned as l-tryptophan, quercetin-3-O-sophoroside, 5,7,3',4'-tetrahydroxyflavonol-3-O-[β-d-rhamnopyranosil-(1→2)]-β-d-glucopyranoside, and quercetin-3-O-glucoside. Each monomer exhibited significant antioxidant activity. The results demonstrated that proposed method could be an effective approach to isolate bioactive compounds from complex natural products.

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Identification and Pharmacokinetics of Multiple Potential Bioactive Constituents after Oral Administration of Radix Astragali on Cyclophosphamide-Induced Immunosuppression in Balb/c Mice

Cited by 49 publications

References 37 publications

Plants in the management of male infertility

Plants in the management of male infertility

Poly‐pharmacokinetic Study of a Multicomponent Herbal Medicine in Healthy Chinese Volunteers

Target-guided isolation of polar antioxidants fromAbelmoschus esculentus(L). Moench by high-speed counter-current chromatography method coupled with wavelength switching and extrusion elution mode

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