Identification and molecular characterization of novel and divergent HoBi-like pestiviruses from naturally infected cattle in India

Mishra, Niranjan; Rajukumar, K.; Pateriya, Atul Kumar; Kumar, Manoj; Dubey, Prashant; Behera, Sthita Pragnya; Verma, Abhishek; Bhardwaj, Pooja; Kulkarni, D. D.; Vijaykrishna, Dhanasekaran; Reddy, Nandakumar D.

doi:10.1016/j.vetmic.2014.09.017

Cited by 54 publications

(94 citation statements)

References 29 publications

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“…In conclusion, the present study reported a HoBi‐like frequency that was similar to the frequency reported in India (Mishra et al., ), but higher than those reported in other regions worldwide. This study extends the epidemiological understanding of HoBi‐like viruses and suggests Northeastern Brazil as a possible original source of this pestivirus species.…”

Section: Discussionsupporting

confidence: 88%

“…A similar study was conducted in Southern Brazil, where BVDV‐1 and BVDV‐2 were detected; however, HoBi‐like viruses were not present (Weber et al., ). It is important to highlight that a recent survey performed in India also found HoBi‐like viruses as the most common bovine pestivirus species present in that subcontinent (Mishra et al., ).…”

Section: Discussionmentioning

confidence: 99%

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HoBi-like is the most prevalent ruminant pestivirus in Northeastern Brazil

Silveira

Baumbach

Weber

et al. 2017

Transbound Emerg Dis

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Summary The ruminant pestiviral species BVDV‐1, BVDV‐2 and BDV, along with the putative species HoBi‐like, may cause substantial economic losses in cattle, sheep and goats. Brazil's large size, variable biomes and wide range of ruminant animal production within different geographic regions suggest that the presence and prevalence of ruminant pestivirus may differ by regions within Brazil. This study investigated the genetic diversity of ruminant pestiviruses and determined the frequency of active infections within two states of the Northeast Region of Brazil, Maranhão and Rio Grande do Norte. Serum samples from 16,621 cattle and 2,672 small ruminants from 569 different herds residing in this region were tested by RT‐PCR followed by DNA sequencing. Seventeen positive cattle were detected (0.1%) from fifteen different herds (2.64%). All isolates were classified as HoBi‐like pestiviruses based on phylogenetic analysis. All small ruminant samples tested negative. The findings presented herein suggest that the Northeast Region of Brazil has a uniquely high prevalence of HoBi‐like viruses. The increasing reports of HoBi‐like viruses detected in cattle in the field suggest that natural infection with these viruses may be more widespread than previously thought. The identification of HoBi‐like viruses as the most prevalent type of ruminant pestivirus circulating in the Northeast Region of Brazil indicates the need for both continued monitoring and determination of the extent of economic losses associated with HoBi‐like virus infections. In addition, it must be taken into account in the choice of diagnostic tests and in vaccine formulations.

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Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 99%

HoBi-like is the most prevalent ruminant pestivirus in Northeastern Brazil

Silveira

Baumbach

Weber

et al. 2017

Transbound Emerg Dis

View full text Add to dashboard Cite

show abstract

“…Further, it appears that there may be regional differences in the presence of HoBi-like virus subgenotypes. Initial limited studies of the genetic distance of HoBilike pestiviruses suggested the presence of an independent evolution of 3 lineages [18]. Comparison of HoBi-like virus sequences previously submitted to GenBank, including recently characterized viruses from India and Bangladesh, and HoBi-like sequences generated in this study suggest the global circulation of at least 4 genetic subgroups, tentatively named 3a-3d.…”

Section: Discussionmentioning

confidence: 63%

“…Recently, HoBi-like viruses have been identified in the Indian subcontinent [18,19] and, in addition, two European laboratories independently detected atypical pestiviral nucleic acids in three commercial batches of FBS that were claimed to be of Australian origin, suggesting a much wider distribution than previously thought [21].…”

Section: Introductionmentioning

confidence: 98%