Identification and measurement of cervical spinal cord atrophy in neuromyelitis optica spectrum disorders (NMOSD) and correlation with clinical characteristics and cervical spinal cord MRI data

Lersy, François; Noblet, Vincent; Willaume, Thibault; Collongues, Nicolas; Kremer, Laurent; Fleury, Marie; Sèze, Jérôme De; Kremer, Stéphane

doi:10.1016/j.neurol.2020.05.007

Cited by 5 publications

(2 citation statements)

References 34 publications

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“…His study investigated 15 patients diagnosed with NMOSD and 15 healthy patient controls. The results showed that the mean CSA was 68.5 mm 2 in the NMO patient population and 72.8 mm 2 in the healthy subject population [ 4 ]. The Paton study showed that NMOSD was a rare autoimmune disorder in which patients experienced relapses affecting the optic nerve, spinal cord, or brainstem.…”

Section: Introductionmentioning

confidence: 99%

Correlation of IgH-CDR3 Immune Repertoire Diversity Test in Peripheral Blood of Neuromyelitis Spectrum Diseases

Peng

Deng

2022

BioMed Research International

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Neuroretinitis spectrum disorder (NMOSD) is generally regarded as an acute or subacute inflammatory demyelinating disease of the central nervous system, mainly involving the optic nerve and spinal cord, mediated by humoral immunity. To address these questions, this work established an immunomic library of the heavy chain complementarity determinant 3 (gHI-CDR3) of peripheral blood lymphocyte B cell receptors. The library was established in patients with a spectrum of neurosyphilis-retinitis disorders. Six NMOSD patients and six healthy volunteers were recruited, and the NMOSD group was divided into an early-onset group and a stable group according to treatment conditions. The IgH-CDR3 gene fragment cultured in vitro was amplified by multiplex PCR technology, and the gene was sequenced by the second-generation high-throughput sequencing technology, and the statistical analysis was carried out by the method without reference. The quantity, type, and diversity of IgH-CDR3 in peripheral blood B lymphocytes of NMOSD patients were significantly lower than those of normal group ( P > 0.05 ); the variation of IgH-CDR3 sequence in the initial stage of treatment was higher than that in the stable stage ( P > 0.05 ); the replication frequency of the characteristic gene “CASSICLGSGCGGYYYGMDVW” was significantly increased in patients at the initial stage of NMOSD treatment ( P < 0.05 ). The conclusion was that the gene expression and gene expression analysis of NMOSD patients could accurately judge the condition of NMOSD patients, evaluate their efficacy, and provide new molecular targets and new theoretical basis for clinical application.

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Section: Introductionmentioning

confidence: 99%

Correlation of IgH-CDR3 Immune Repertoire Diversity Test in Peripheral Blood of Neuromyelitis Spectrum Diseases

Peng

Deng

2022

BioMed Research International

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“…Those five patients each showed a significant increase in volume during follow-up: whole-brain normalized volume +5.9%, GM normalized volume +1.4%, WM normalized volume +10%. This was expected, since corticosteroids are known to lead to reductions in volume after they are newly started, an effect lasting from weeks to months [ 18 , 19 ]. The brain volumes had probably transiently decreased at the time of the first MRI; that is why we chose to exclude these five patients from the complementary analyses.…”

Section: Resultsmentioning

confidence: 99%

Evolution of Neuroimaging Findings in Severe COVID-19 Patients with Initial Neurological Impairment: An Observational Study

Lersy

Bund

Anheim

et al. 2022

Viruses

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Background and Objectives: Cerebral complications related to the COVID-19 were documented by brain MRIs during the acute phase. The purpose of the present study was to describe the evolution of these neuroimaging findings (MRI and FDG-PET/CT) and describe the neurocognitive outcomes of these patients. Methods: During the first wave of the COVID-19 outbreak between March 1 and May 31, 2020, 112 consecutive COVID-19 patients with neurologic manifestations underwent a brain MRI at Strasbourg University hospitals. After recovery, during follow-up, of these 112 patients, 31 (initially hospitalized in intensive care units) underwent additional imaging studies (at least one brain MRI). Results: Twenty-three men (74%) and eight women (26%) with a mean age of 61 years (range: 18–79) were included. Leptomeningeal enhancement, diffuse brain microhemorrhages, acute ischemic strokes, suspicion of cerebral vasculitis, and acute inflammatory demyelinating lesions were described on the initial brain MRIs. During follow-up, the evolution of the leptomeningeal enhancement was discordant, and the cerebral microhemorrhages were stable. We observed normalization of the vessel walls in all patients suspected of cerebral vasculitis. Four patients (13%) demonstrated new complications during follow-up (ischemic strokes, hypoglossal neuritis, marked increase in the white matter FLAIR hyperintensities with presumed vascular origin, and one suspected case of cerebral vasculitis). Concerning the grey matter volumetry, we observed a loss of volume of 3.2% during an average period of approximately five months. During follow-up, the more frequent FDG-PET/CT findings were hypometabolism in temporal and insular regions. Conclusion: A minority of initially severe COVID-19 patients demonstrated new complications on their brain MRIs during follow-up after recovery.

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Serum neurofilament light chain predicts spinal cord atrophy in neuromyelitis optica spectrum disorder

Li,

Liu,

Zhao

et al. 2023

Journal of Neuroimmunology

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Identification and measurement of cervical spinal cord atrophy in neuromyelitis optica spectrum disorders (NMOSD) and correlation with clinical characteristics and cervical spinal cord MRI data

Cited by 5 publications

References 34 publications

Correlation of IgH-CDR3 Immune Repertoire Diversity Test in Peripheral Blood of Neuromyelitis Spectrum Diseases

Correlation of IgH-CDR3 Immune Repertoire Diversity Test in Peripheral Blood of Neuromyelitis Spectrum Diseases

Evolution of Neuroimaging Findings in Severe COVID-19 Patients with Initial Neurological Impairment: An Observational Study

Serum neurofilament light chain predicts spinal cord atrophy in neuromyelitis optica spectrum disorder

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