Identification and Localization of MEP1A-like Sequences (MEP1AL1-4) in the Human Genome

Jiang, Weiping; Beatty, Barbara

doi:10.1006/bbrc.1999.1008

Cited by 5 publications

(1 citation statement)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…All nine polymorphisms were genotyped in 379 UC and 380 CD patients as well as in 372 healthy controls. The human genome contains multiple copies of MEP1A-like sequences on chromosome 9 20. Owing to the presence of these pseudogenes that share high sequence similarities with the meprin-α gene on chromosome 6, a MEP1A -specific sequencing strategy was developed.…”

Section: Resultsmentioning

confidence: 99%

MEP1A allele for meprin A metalloprotease is a susceptibility gene for inflammatory bowel disease

et al. 2009

View full text Add to dashboard Cite

The MEP1A gene, located on human chromosome 6p (mouse chromosome 17) in a susceptibility region for inflammatory bowel disease (IBD), encodes the α-subunit of metalloproteinase meprin A, which is expressed in the intestinal epithelium. This study shows a genetic association of MEP1A with IBD in a cohort of ulcerative colitis (UC) patients. There were four single-nucleotide polymorphisms in the coding region (P = 0.0012-0.04), and one in the 3′-untranslated region (P = 2×10 −7 ) that displayed associations with UC. Moreover, meprin-α mRNA was decreased in inflamed mucosa of IBD patients. Meprin-α knockout mice exhibited a more severe intestinal injury and inflammation than their wild-type counterparts following oral administration of dextran sulfate sodium. Collectively, the data implicate MEP1A as a UC susceptibility gene and indicate that decreased meprin-α expression is associated with intestinal inflammation in IBD patients and in a mouse experimental model of IBD.

show abstract

Section: Resultsmentioning

confidence: 99%