Identification and isolation of putative stem cells from the murine placenta

Abstract

The mid-gestation murine placenta may serve as a source of multipotent stem cells and also contains cells which may be renal cell progenitors.

The Placenta as an Organ and a Source of Stem Cells and Extracellular Matrix: A Review

“…Placenta-derived stem cells are multipotent [Zhang et al, 2004;Fierabracci et al, 2015;Shafiee et al, 2015] and can be isolated from distinct components, e.g. the fetal and maternal portions of the placenta, amniotic membrane and fluid, chorion, umbilical cord and cord blood [In't Anker et al, 2004;Mihu et al, 2008;Parolini et al, 2008;Corradetti et al, 2011;Vellasamy et al, 2012;Makhoul et al, 2013;Patel et al, 2014;Proudfit et al, 2014;Fierabracci et al, 2015;Kmiecik et al, 2015;Shafiee et al, 2015]. Furthermore, stem cells are widely accepted to reside in a perivascular niche in virtually all organs, including the placenta [Caplan, 2008;Crisan et al, 2008;da Silva Meirelles et al, 2008;Castrechini et al, 2010;Corselli et al, 2010;Park et al, 2011;Asatrian et al, 2015].…”

“…Stem cells derived from the fetal portion of the placenta express slightly higher levels of CD146 and nestin compared to bone marrow-derived stem cells, and are negative for CD271, which is very low in bone marrow cells [RosonBurgo et al, 2014]. Differences in the expression of antigens have been described, not only among stem cells isolated from various parts of the placenta [Roson-Burgo et al, 2014;Kmiecik et al, 2015;Kuchma et al, 2015], but also among placental stem cells isolated at various gestational ages [Jones et al, 2012;Proudfit et al, 2014;Lankford et al, 2015] and among placentas derived from mothers of different ages [Alrefaei et al, 2015].…”