Identification and isolation of medicarpin and a substituted benzofuran as potent leukotriene inhibitors in an anti-inflammatory Chinese herb

Miller, Douglas K.; Sadowski, S.; Han, Gui-Qiu; Joshua, H

doi:10.1016/0952-3278(89)90098-7

Cited by 19 publications

(10 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Examples for plant species containing 5-lipoxygenase inhibitory compounds with IC 50 values below 1 µm are: Atractylodes lancea , Isatis tinctoria (Danz et al, 2002), Isatis indigotica (Molina et al, 2001), Linaria saxatilis (Benrezzouk et al, 1999), Haplophyllum hispanicum (Prieto et al, 2002), Plantago asiatica (Ravn et al, 1990), Chelidonium majus (Vavreckova et al, 1996), Artocarpus communis (Reddi et al, 1991), Salvia aethiopis (Benrezzouk et al, 2001), Belamcanda chinensis (Fukuyama et al, 1991), Glycyrrhiza inflata (Yoshiyuki, 1995), Dalbergia odorifera (Sunil Kumar and Müller, 1998;Miller et al, 1989) and Asiasarum sieboldii (Hashimoto et al, 1994).…”

Section: As Illustrated Inmentioning

confidence: 98%

Lipoxygenase inhibitors from natural plant sources. Part 1: Medicinal plants with inhibitory activity on arachidonate 5‐lipoxygenase and 5‐lipoxygenase[sol ]cyclooxygenase

Schneider

Bučar

2005

Phytotherapy Research

117

View full text Add to dashboard Cite

Arachidonate 5-lipoxygenase is the key enzyme in leukotriene biosynthesis and catalyses the initial steps in the conversion of arachidonic acid to biologically active leukotrienes. Leukotrienes are considered as potent mediators of inflammatory and allergic reactions and regarding their pro-inflammatory properties the inhibition of 5-lipoxygenase pathway is considered to be interesting in the treatment of a variety of inflammatory diseases. Besides 5-lipoxygenase inhibitors, drugs able to block the 5-lipoxygenase as well as the cyclooxygenase metabolic pathway are also of therapeutic value. A potential source for new 5-lipoxygenase inhibitors is undoubtedly provided by the abundance of medicinal plants used in traditional medicine. The present review article reports the results from a comprehensive literature search of plants that have been tested for 5-lipoxygenase inhibitory activity over the past 15 years. The obtained information is summarized in a tabular format and promising plant species and chemical classes of compounds are presented. Relevant in vitro tests are also described in this article.

show abstract

Section: As Illustrated Inmentioning

confidence: 98%

Lipoxygenase inhibitors from natural plant sources. Part 1: Medicinal plants with inhibitory activity on arachidonate 5‐lipoxygenase and 5‐lipoxygenase[sol ]cyclooxygenase

Schneider

Bučar

2005

Phytotherapy Research

117

View full text Add to dashboard Cite

show abstract

“…Many reports described the 5-lipoxygenase inhibitory activities of medicinal plants. However, the vast proportion of these reports deal with isolated compounds such as acetyl-11-keto-␤ -boswellic acid, medicarpin, and nigellone D [10][11][12] . In addition, the vast majority of studies investigating the potential 5-lipoxygenase inhibitory activity of medicinal plants utilize 'whole-cell' systems such as polymorphonuclear cells and leucocytes without tandem toxicity studies [8] .…”

Section: Frum /Viljoenmentioning

confidence: 99%

In vitro 5-Lipoxygenase and Anti-Oxidant Activities of South African Medicinal Plants Commonly Used Topically for Skin Diseases

Frum

Viljoen

2006

Skin Pharmacol Physiol

View full text Add to dashboard Cite

An investigation was undertaken to determine the possible mechanisms of action of medicinal plants used for dermatological pathologies. A total of 14 plant species were selected from the readily available ethnobotanical literature. 5-Lipoxygenase and DPPH (2,2-diphenyl-1-picrylhydrazyl) assays were used to determine the anti-inflammatory activity and the anti-oxidant activity of selected medicinal plants, respectively. Both aqueous and methanol extracts were tested. Among the plants screened, four species (Croton sylvaticus, Warburgia salutaris, Pentanisia prunelloides, and Melianthus comosus) displayed promising 5-lipoxygenase inhibitory activity with IC₅₀ values <61 ppm. A large number of plants exhibited significant anti-oxidant activities with IC₅₀ values between 5.27 and 83.36 ppm. Aqueous extracts of M. comosus exhibited the most potent anti-inflammatory and anti-oxidant activity.

show abstract

“…Remarkably potent polyphenols that inhibit 5-LO in cellular as well as in cell-free assays in the submicromolar range are the benzofuran derivatives medicarpin 50 and 6-hydroxy-2-(2-hydroxy-4-methoxyphenyl)benzofuran 51 from the Chinese plant Dalbergia odorifera (Jiangxiang) (IC 50 = 50 ± 500 nM) [117], 3,4,2¢,4¢-tetrahydroxy-2-geranyldihydrochalcone 60 from Artocarpus communis (IC 50 = 0.05 ± 1 mM) [120] and the acylphloroglucinols hyperforin 48 (IC 50 = 0.09 ± 1.2 mM) from St. John's wort (Hypericum perforatum L.) [119], and myrtucommulone 49 (IC 50 = 1.8±5 mM) from myrtle (Myrtus communis L.) [126]. These compounds may be regarded as potent and direct 5-LO inhibitors.…”

Section: Inhibitors Of 5-lo Product Synthesis From Plant Originmentioning

confidence: 99%

Inhibition of 5-Lipoxygenase Product Synthesis by Natural Compounds of Plant Origin

Werz¹

2007

Planta Med

151

135

View full text Add to dashboard Cite

The biosynthesis of leukotrienes (LTs) is initiated by the transformation of free arachidonic acid to LTA 4 by 5-lipoxygenase (5-LO). Subsequent enzymatic conversion of LTA 4 yields LTB 4 and the cysteinyl-LTs C 4 , D 4 and E 4 . LTs have prominent functions in pathophysiology and are connected to numerous disorders including bronchial asthma, allergic rhinitis, inflammatory bowel and skin diseases, rheumatoid arthritis, cancer, osteoporosis and cardiovascular diseases. Pharmacological and genetic interruption of the 5-LO pathway or blockade of LT receptors, serving as means for intervention with LTs, may be of therapeutic value for certain related disorders. Natural or plant-derived substances were among the first 5-LO inhibitors identified in the early 1980 s. To date, a huge number of diverse plant-derived compounds have been reported to interfere with 5-LO product synthesis. However, many investigations have addressed the efficacy of a given compound solely in cellular test systems and analysis of direct interference with 5-LO has been neglected. In the first part of this review, the biology and molecular pharmacology of the 5-LO pathway is summarized in order to understand its overall regulation and complexity as well as to comprehend the possible points of attack of compounds that eventually lead to inhibition of 5-LO product formation in intact cells. In the second part, natural compounds that interfere with 5-LO product formation are compiled and grouped into structural classes, and the underlying molecular mechanisms and structureactivity relationships are discussed.

show abstract

Identification and isolation of medicarpin and a substituted benzofuran as potent leukotriene inhibitors in an anti-inflammatory Chinese herb

Cited by 19 publications

References 12 publications

Lipoxygenase inhibitors from natural plant sources. Part 1: Medicinal plants with inhibitory activity on arachidonate 5‐lipoxygenase and 5‐lipoxygenase[sol ]cyclooxygenase

Lipoxygenase inhibitors from natural plant sources. Part 1: Medicinal plants with inhibitory activity on arachidonate 5‐lipoxygenase and 5‐lipoxygenase[sol ]cyclooxygenase

In vitro 5-Lipoxygenase and Anti-Oxidant Activities of South African Medicinal Plants Commonly Used Topically for Skin Diseases

Inhibition of 5-Lipoxygenase Product Synthesis by Natural Compounds of Plant Origin

Contact Info

Product

Resources

About