Identification and interruption of inheritance of familial cryptic translocations: A case report
Jian Ou,
Jian Sun,
Chuan‐Chun Yang
et al.
Abstract:BackgroundCryptic translocations can be identified via genetic analysis of aborted tissues or malformed infants, but it is difficult to deduce the parental origins of the translocations. In the absence of such information, it is not easy to distinguish translocations from normal embryos during pre‐implantation genetic testing, that seeks to block familial transmission of translocations.MethodsHere, we present a new method that detects cryptic translocations and blocks familial transmission thereof. Whole‐genom… Show more
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