Identification and experimental validation of key extracellular proteins as potential targets in intervertebral disc degeneration
Guang-Zhi Zhang,
Lei Li,
Zhang-Bin Luo
et al.
Abstract:AimsThis study aimed, through bioinformatics analysis and in vitro experiment validation, to identify the key extracellular proteins of intervertebral disc degeneration (IDD).MethodsThe gene expression profile of GSE23130 was downloaded from the Gene Expression Omnibus (GEO) database. Extracellular protein-differentially expressed genes (EP-DEGs) were screened by protein annotation databases, and we used Gene Ontology (GO) and the Kyoto Encyclopedia of Genes and Genomes (KEGG) to analyze the functions and path… Show more
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