Identification and drug-induced reversion of molecular signatures of Alzheimer’s disease onset and progression inAppNL-G-F,AppNL-Fand 3xTg-AD mouse models
Abstract:Alzheimers disease (AD) is the most common form of dementia. Over fifty years of intense research have revealed many key elements of the biology of this neurodegenerative disorder. However, our understanding of the molecular bases of the disease is still incomplete, and the medical treatments available for AD are mainly symptomatic and hardly effective. Indeed, the robustness of biological systems has revealed that the modulation of a single target is unlikely to yield the desired outcome and we should therefo… Show more
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