Identification and Differentiation of Organic Medicinal Agents II

Doan, Lynn A.; Ghatten, Leslie G.

doi:10.1002/jps.2600541110

Cited by 5 publications

(1 citation statement)

References 39 publications

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“…Another source of unrecognized cocrystals is contained within the extensive scope of analytical chemistry conducted under the general category of chemical microscopy, where analysts would prepare derivatives or adducts of an analyte species and then identify the analyte on the basis of the morphology of the crystalline products [12,13]. For example, Clarke developed sensitive microchemical tests for the determination of anesthetics [14], antihistamines [15], antimalarials [16], and analgesics [17], while Chatten and coworkers developed chemical microscopic methods for the identification and differentiation of local anesthetics [18], muscle relaxants [19], and amine-containing compounds [20].…”

Section: Introductionmentioning

confidence: 99%

Vibrational Spectroscopic Study of the Cocrystal Products Formed by Cinchona Alkaloids with 5-Nitrobarbituric Acid

Brittain¹

2015

Journal of Spectroscopy

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X-ray powder diffraction, differential scanning calorimetry, infrared absorption spectroscopy, and Raman spectroscopy have been used to study the phenomenon of cocrystal formation in the molecular complexes formed by 5-nitrobarbituric acid with four cinchona alkaloids. The cocrystal products were found to contain varying degrees of hydration, ranging from no hydration in the nitrobarbiturate-quinidine cocrystal up to a 4.5-hydrate species in the nitrobarbiturate-cinchonine cocrystal. For the nitrobarbiturate cocrystals with cinchonine, cinchonidine, and quinidine, the predominant interaction was with the quinoline ring system of the alkaloid. However, for quinine, the predominant interaction was with the quinuclidine group of the alkaloid. These properties serve to demonstrate the utility of 5-nitrobarbituric acid as a preferred reagent for chemical microscopy, since the differing range of hydrate and structural types would serve to easily differentiate the cinchona alkaloids from each other, even when different compounds contained the same absolute configurations at their dissymmetric centers.

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