Identification and determination of major flavonoids in rat serum by HPLC–UV and HPLC–MS methods following oral administration of Dalbergia odorifera extract

The relationship between structure and in vitro antibacterial activity of selected isoflavones and their metabolites with special focus on antistaphylococcal effect of demethyltexasin

“…), and occurrence of formononetin in rat serum at C max 5·4 μ g ml −1 after oral intake of Dalbergia extract (Liu et al . ), which is in correspondence with C max levels of commonly use antistaphylococcal antibiotics. These findings suggest potential contribution to the suppression of staphylococcal infections by consumption of 6 in an adequate quantity, for example in the fermented soya‐based food, but other pharmacokinetic/pharmacodynamic (PK/PD) modelling will be necessary to support this hypothesis.…”

Inhibitory effect of 9-hydroxy-6,7-dimethoxydalbergiquinol from Dalbergia odorifera on the NF-κB-related neuroinflammatory response in lipopolysaccharide-stimulated mouse BV2 microglial cells is mediated by heme oxygenase-1

“…For these reasons, natural products-derived compounds such as HDDQ may be better than the currently other synthetic drugs. Taken together, we have been conducting researches focused on the identification of HO-1 regulating natural products and the investigation of their mechanism of the biological effects against the various types of diseases [21][22][23][24][25][26]. In the present study, we investigated the potential involvement of HO-1 expression through nuclear translocation of Nrf2 in the anti-neuroinflammatory activity of HDDQ, one of the major flavonoids isolated from D. odorifera.…”

A sensitive liquid chromatography–mass spectrometry method for simultaneous determination of two active chromones from Saposhnikovia root in rat plasma and urine

“…Because of little report on chromones, in the early method development stage, we investigated different extraction ways according to the studies of the other TCM [19][20][21], such as liquid-liquid extrac- tion (LLE), protein precipitation (PPT), aqueous bath extraction. Aether, ethyl acetate, ethyl acetate-isopropanol (95:5, v/v), and n-hexane-dichloromethane-isopropanol (5:4:1, v/v/v) was also tested as the extraction solvent.…”