Identification and characterization of Zic4, a new member of the mouse Zic gene family

Aruga, Jun; Yozu, Arito; Hayashizaki, Yoshihide; Okazaki, Yasushi; Chapman, Verne M.; Mikoshiba, Katsuhiko

doi:10.1016/0378-1119(96)00111-4

Cited by 66 publications

(26 citation statements)

References 15 publications

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“…opl/zic1 belongs to the zic gene family whose members are characterized by patterned expression in the gastrula ectoderm (Kuo et al, 1998;Nagai et al, 1997;Nakata et al, 1997Nakata et al, , 1998. Modern members of the zic family are likely to have originated from a single common ancestor gene, because intron positions are precisely conserved in Drosophila opa (Benedyk et al, 1994), mouse zic genes (Aruga et al, 1996b), and zebrafish opl (Grinblat et al, 1998). There are at least three, and as many as five, distinct zic genes found in each of the vertebrate species examined (Furushima et al, 2000;Nakata et al, 2000).…”

Section: Results and Discussion Isolation Of Zebrafish Zic Genesmentioning

confidence: 99%

zic Gene expression marks anteroposterior pattern in the presumptive neurectoderm of the zebrafish gastrula

Grinblat

Sive

2001

Developmental Dynamics

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Anteroposterior (A/P) patterning of the vertebrate neurectoderm begins early during development. In vitro explant assays have been used to show that an A/P subdivision of the zebrafish neurectoderm is in place by early gastrulation. However, no direct markers of this subdivision had been described. We report isolation of two members of the zic gene family, zic2 and zic3, which mark distinct regions in the developing nervous system. zic3 is expressed in early gastrula embryos in a posterior domain, directly demonstrating that A/P pattern is present in the future neurectoderm by this stage. Analysis of mutants in genes encoding bone morphogenetic proteins (BMPs) shows that dorsal restriction of zic3 expression requires intact BMP function, and that posterior restriction of zic3 expression is regulated independently of BMP signaling. These data show an early subdivision of the A/P axis in the presumptive neurectoderm.

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Section: Results and Discussion Isolation Of Zebrafish Zic Genesmentioning

confidence: 99%

zic Gene expression marks anteroposterior pattern in the presumptive neurectoderm of the zebrafish gastrula

Grinblat

Sive

2001

Developmental Dynamics

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“…Targeted homozygous null Zic1 mutant mice have severe cerebellar hypoplasia with folial mispatterning. Zic4 was initially identified in mice based on its homology to Zic1 but has not been characterized 14 . We found that mouse Zic4 was expressed in the dorsal central nervous system, including the developing cerebellum and spinal cord, in a pattern that overlaps with expression of Zic1 ( Supplementary Fig.…”

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confidence: 99%

Heterozygous deletion of the linked genes ZIC1 and ZIC4 is involved in Dandy-Walker malformation

Northrup²,

et al. 2004

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“…We predict the presence of a fifth gene, Zic4, in Xenopus based on a correlation between mammalian and amphibian Zic genes. Zic4 was originally described in mouse cerebellum (Aruga et al, 1996b). Mouse Zic4 expression partially overlaps, but is distinct from, other mouse Zic genes during embryonic development (Ding et al, 2004;Gaston-Massuet et al, 2005), and transcriptional activation and target protein binding differ between (Zic4 and Zic5) and (Zic1, Zic2, and Zic3) subgroups (Ishiguro et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

Xenopus Zic4: Conservation and diversification of expression profiles and protein function among the Xenopus Zic family

Fujimi

Mikoshiba

Aruga

2006

Developmental Dynamics

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We compared the expression and function of Xenopus Zic4 with those of the other four Xenopus laevis Zic family members (Zic1, Zic2, Zic3, and Zic5). Zic4 expression was detected mainly in the neural plate border, dorsal neural tube, and somites, and was similar to that of Zic1, which is adjacent to Zic4 on the same chromosome. Injection of wild-type or mutant Zic4 RNA caused the induction of neural crest marker gene expression, hyperplastic neural tissue, and ectopic pigment cell formation, indicating that Zic4 can induce neural and neural crest tissue, as can other Xenopus Zic genes. Deletion analysis showed that the zinc-finger domain is critical for many Zic4 functions, but the C-terminal region is differently involved in induction of two neural crest markers, Slug and Sox10. The protein function as determined by the animal cap explant assay was similar to that of Zic5, but different from those of Zic1, Zic2, and Zic3, suggesting that Xenopus Zic genes can be divided into two groups based on function. These results indicate that the five Xenopus Zic genes cooperatively regulate both neural and neural crest development, despite significantly diverged expression profiles and functions. Developmental Dynamics 235:3379 -3386, 2006.

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Identification and characterization of Zic4, a new member of the mouse Zic gene family

Cited by 66 publications

References 15 publications

zic Gene expression marks anteroposterior pattern in the presumptive neurectoderm of the zebrafish gastrula

zic Gene expression marks anteroposterior pattern in the presumptive neurectoderm of the zebrafish gastrula

Heterozygous deletion of the linked genes ZIC1 and ZIC4 is involved in Dandy-Walker malformation

Xenopus Zic4: Conservation and diversification of expression profiles and protein function among the Xenopus Zic family

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