Identification and Characterization of Two New Methylicosadienoic Acids from Erylus formosus

Abstract

The novel fatty acids 18-methyl-5,9-icosadienoic acid [1] and 19-methyl-5,9-icosadienoic acid [2] were identified in the Caribbean sponge Erylus formosus. Other interesting fatty acids identified were the branched acids 3-methylpentadecanoic acid and 3-methylhexadecanoic acid, which are known to possess larvicidal activity. The most stable conformation of the new acid 19-methyl-5,9-icosadienoic acid is also presented as predicted by Molecular Mechanics (MM2) calculations. The sterol composition of E. formosus is also reported.

Morphological description and DNA barcodes of shallow-water Tetractinellida (Porifera: Demospongiae) from Bocas del Toro, Panama, with description of a new species

“…Distribution. Florida Keys, USA Kubanek et al 2000); Bahamas (Wiedenmayer 1977;Pulitzer-Finali 1986;Stead et al 2000); Cuba (Alcolado 2002); Puerto-Rico (Carballeira & Negrón 1991); Jamaica (Lehnert & van Soest 1998); Virgin Islands (USNM 31489, 31579, 41227); Dominican Republic (Pulitzer-Finali 1986); Curaçao (van Soest 1981); Mexico (Lehnert 1993;Antonov et al 2007); Belize (USNM 32377); Panama (Collin et al 2005;Díaz 2005); Venezuela (Alvarez et al 1991); Brazil (Sollas 1888;Boury-Esnault 1973;Volkmer-Ribeiro & de Moraes 1975;Solé Cava et al 1981;Mothes et al 1999) Remarks and discussion. ZMBN 81644 fitted the description of E. bahamensis Pulitzer-Finali, 1986 while ZMBN 81645 fitted the description of E. formosus.…”

Marine natural products

“…'~' Kuhukuenes A (143) and B ( 144) are unusual brominated diterpenes that were isolated from a Hawaiian specimen of L. majusculu and identified by spectroscopic methods.138 Intricatetrol (145) is a halogenated triterpene with C, symmetry that was isolated from L. intricata from Japan. The structure and much of the stereochemistry of intricatetrol (145) was elucidated by spectroscopic and chemical A total synthesis of the stereoisomers of (+)-nidifocene (146), which is a metabolite of…”

The antimicrobial activity of heterotrophic bacteria isolated from the marine sponge Erylus deficiens (Astrophorida, Geodiidae)

“…Furthermore, Erylus spp. are well known producers of oligoglycosides with antifeedant activity involved in chemical defenses of sponges against predatory fish (Kubanek et al, 2000 ; Kubanek and Fenical, 2001 ; Antonov et al, 2011 ) and with larvicidal activity (Carballeira and Negrón, 1991 ). Crude extracts of Erylus deficiens from the Portuguese coast were found to possess indoleamine 2,3-dioxygenase (IDO) inhibitory activity (Gaspar et al, 2012 ).…”