Identification and characterization of tryptophan-kynurenine pathway-related genes involving lamprey (Lampetra japonica) innate immunity

Luan, Yimu; Wang, Yaocen; Zhang, Wentong; Duan, Xuyuan; Su, Peng; Li, Qingwei; Pang, Yue; Gou, Meng

doi:10.1016/j.fsi.2023.108967

Cited by 3 publications

(1 citation statement)

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“…In addition, in rainbow trout, the kidney was shown to present necrosis in epithelia, tubules, and glomerulus in practically all KYNA-supplemented groups; similar problems were presented in gills with fusion or disappearance of gill lamellae, of course affecting the osmoregulation and respiratory activity [33,52]. The TRP-KYN pathway in lamprey leukocytes (Lampetra japonica) was activated by adding TRP [53] and overexpression significantly reduced TNF-α and NF-κβ expression and clarified the ancestral features and functions of the TRP-KYN pathway. Meanwhile, Machado et al (2021) [54] indicated that the tryptophan presented a clear role in the tolerance process responsible for restriction of the pro-inflammatory cluster of the immune response in Head Kidney Leucocytes (HKLs) of European seabass.…”

Section: Discussionmentioning

confidence: 88%

Tryptophan and Cortisol Modulate the Kynurenine and Serotonin Transcriptional Pathway in the Kidney of Oncorhynchus kisutch

Vargas-Chacoff,

Nualart,

Vargas-Lagos

et al. 2023

Animals

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Aquaculture fish are kept for long periods in sea cages or tanks. Consequently, accumulated stress causes the fish to present serious problems with critical economic losses. Fish food has been supplemented to reduce this stress, using many components as amino acids such as tryptophan. This study aims to determine the transcriptional effect of tryptophan and cortisol on primary cell cultures of salmon head and posterior kidney. Our results indicate activation of the kynurenine pathway and serotonin activity when stimulated with tryptophan and cortisol. An amount of 95% of tryptophan is degraded by the kynurenine pathway, indicating the relevance of knowing how this pathway is activated and if stress levels associated with fish culture trigger its activation. Additionally, it is essential to know the consequence of increasing kynurenic acid “KYNA” levels in the short and long term, and even during the fish ontogeny.

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