Identification and Characterization of Small Non‐coding RNAs in Bacteria

Podkaminski, Dimitri; Bouvier, Marlène; Vogel, Jörg

doi:10.1002/9783527647064.ch33

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Srnas In Mycobacteria1

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2014

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References 187 publications

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“…Mycobacterial sRNA studies may pursue PAR-CLIP or other CLIP variations to obtain strand-specific binding insight in the future. Other technologies are available for characterization of discovered sRNA interactions including reporter gene fusions ( gfp, lacZ, luc ), in vitro RNA-RNA footprinting, and in vitro toeprinting (Podkaminski et al, 2014 ). In particular, toeprinting has been successful in characterizing sRNAs that negatively regulate their targets.…”

Section: Srnas In Mycobacteriamentioning

confidence: 99%

Small RNAs in mycobacteria: an unfolding story

Haning

Cho

Contreras

2014

Front. Cell. Infect. Microbiol.

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Mycobacteria represent a class of powerful pathogens, including those causing tuberculosis and leprosy, which continue to be worldwide health challenges. In the last 20 years, an abundance of non-coding, small RNAs (sRNAs) have been discovered in model bacteria and gained significant attention as regulators of cellular responses, including pathogenesis. Naturally, a search in mycobacteria followed, revealing over 200 sRNAs thus far. Characterization of these sRNAs is only beginning, but differential expression under environmental stresses suggests relevance to mycobacterial pathogenesis. This review provides a comprehensive overview of the current knowledge of sRNAs in mycobacteria, including historical perspective and techniques used for identification and characterization.

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Section: Srnas In Mycobacteriamentioning

confidence: 99%