Identification and Characterization of Rhipicephalus microplus ATAQ Homolog from Haemaphysalis longicornis Ticks and Its Immunogenic Potential as an Anti-Tick Vaccine Candidate Molecule

Moumouni, Paul Franck Adjou; Naomasa, Souichirou; Tuvshintulga, Bumduuren; Sato, Nariko; Okado, Kiyoshi; Zheng, Weiqing; Lee, Seunghun; Mosqueda, Juan; Suzuki, Hiroshi; Xu, Xuan; Umemiya‐Shirafuji, Rika

doi:10.3390/microorganisms11040822

Cited by 3 publications

(1 citation statement)

References 46 publications

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“…A vaccine efficacy of ~35% was obtained in cattle vaccination trials against R. microplus infestations [ 104 ]. An ATAQ orthologue, rHlATAQ, was also tested in rabbit vaccination trials infested with Haemaphysalis longicornis with little effect [ 114 ]. It was suggested that this antigen could be better utilised as a component of a multivalent vaccine to improve the efficacy of other vaccine antigens [ 104 ].…”

Section: First Encounter With the Antigen Diversity-driven Bottleneck...mentioning

confidence: 99%

More than Three Decades of Bm86: What We Know and Where to Go

Bishop,

Stutzer,

Maritz-Olivier

2023

Pathogens

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Tick and tick-borne disease control have been a serious research focus for many decades. In a global climate of increasing acaricide resistance, host immunity against tick infestation has become a much-needed complementary strategy to common chemical control. From the earliest acquired resistance studies in small animal models to proof of concept in large production animals, it was the isolation, characterization, and final recombinant protein production of the midgut antigen Bm86 from the Australian cattle tick strain of Rhipicephalus (Boophilus) microplus (later reinstated as R. (B.) australis) that established tick subunit vaccines as a viable alternative in tick and tick-borne disease control. In the past 37 years, this antigen has spawned numerous tick subunit vaccines (either Bm86-based or novel), and though we are still describing its molecular structure and function, this antigen remains the gold standard for all tick vaccines. In this paper, advances in tick vaccine development over the past three decades are discussed alongside the development of biotechnology, where existing gaps and future directives in the field are highlighted.

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Section: First Encounter With the Antigen Diversity-driven Bottleneck...mentioning

confidence: 99%

More than Three Decades of Bm86: What We Know and Where to Go

Bishop,

Stutzer,

Maritz-Olivier

2023

Pathogens

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Hemalin vaccination modulates the host immune response and reproductive cycle of Haemaphysalis longicornis

Ma,

Ai,

et al. 2023

Veterinary Parasitology

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Rabbits as Animal Models for Anti-Tick Vaccine Development: A Global Scenario

Rodríguez-Durán,

Ullah,

Parizi

et al. 2023

Pathogens

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Studies evaluating candidate tick-derived proteins as anti-tick vaccines in natural hosts have been limited due to high costs. To overcome this problem, animal models are used in immunization tests. The aim of this article was to review the use of rabbits as an experimental model for the evaluation of tick-derived proteins as vaccines. A total of 57 tick proteins were tested for their immunogenic potential using rabbits as models for vaccination. The most commonly used rabbit breeds were New Zealand (73.8%), Japanese white (19%), Californians (4.8%) and Flemish lop-eared (2.4%) rabbits. Anti-tick vaccines efficacy resulted in up to 99.9%. Haemaphysalis longicornis (17.9%) and Ornithodoros moubata (12.8%) were the most common tick models in vaccination trials. Experiments with rabbits have revealed that some proteins (CoAQP, OeAQP, OeAQP1, Bm86, GST-Hl, 64TRP, serpins and voraxin) can induce immune responses against various tick species. In addition, in some cases it was possible to determine that the vaccine efficacy in rabbits was similar to that of experiments performed on natural hosts (e.g., Bm86, IrFER2, RmFER2, serpins and serine protease inhibitor). In conclusion, results showed that prior to performing anti-tick vaccination trials using natural hosts, rabbits can be used as suitable experimental models for these studies.

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Identification and Characterization of Rhipicephalus microplus ATAQ Homolog from Haemaphysalis longicornis Ticks and Its Immunogenic Potential as an Anti-Tick Vaccine Candidate Molecule

Cited by 3 publications

References 46 publications

More than Three Decades of Bm86: What We Know and Where to Go

More than Three Decades of Bm86: What We Know and Where to Go

Hemalin vaccination modulates the host immune response and reproductive cycle of Haemaphysalis longicornis

Rabbits as Animal Models for Anti-Tick Vaccine Development: A Global Scenario

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