Identification and characterization of novel developmentally regulated neural-specific proteins, BRINP family

Kawano, Hiroyuki; Nakatani, Tomoaki; Mori, Toshio; Ueno, Satoshi; Fukaya, Masahiro; Abe, Asami; Kobayashi, Miwako; Toda, F.; Watanabe, Masahiko; Matsuoka, Isao

doi:10.1016/j.molbrainres.2004.04.001

Cited by 73 publications

(87 citation statements)

References 46 publications

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“…Hence we propose that BRINP family proteins are involved in the key events of neural development, such as cessation of cell proliferation and neuronal differentiation. BRINP family mRNA expression is also observed in neuronal cell layers and nuclei of the adult brain [4]. These finding suggests that BRINP family genes also play an important role in the adult brain presumably in neuronal cells.…”

Section: Introductionmentioning

confidence: 63%

“…The primary structures of the protein products have been highly conserved during evolution and show no similarity to other known proteins. We have shown that BRINP family proteins suppress cell cycle progression of various cell types including differentiating neural stem cells [4]. Hence we propose that BRINP family proteins are involved in the key events of neural development, such as cessation of cell proliferation and neuronal differentiation.…”

Section: Introductionmentioning

confidence: 82%

“…3B). These results indicate that membrane depolarization can induce BRINP1-mRNA mainly through the influx of Ca [4]. We then examined the effects of those factors on the levels of BRINP1-mRNA in the cultured hippocampal neurons.…”

Section: Regulation Of Brinp Family Mrna In Cultured Hippocampal Neuronsmentioning

confidence: 98%

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Activity-dependent regulation of BRINP family genes

Motomiya

Kobayashi

Iwasaki

et al. 2007

Biochemical and Biophysical Research Communications

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We previously identified a family of novel developmentally regulated genes: BRINP1, 2, and 3, which are predominantly and widely expressed in the CNS from earlier developmental stages to adulthood. In the present study, we investigated the activity-dependent regulation of BRINP expression in the CNS. Among the three BRINP genes, BRINP1-mRNA was specifically up-regulated in the dentate gyrus of mouse hippocampus by kainic acid treatment.In cultured hippocampal neurons, the induction of BRINP1-mRNA was also observed by the activation of glutamate receptors. Although BDNF-mRNA is up-regulated in a similar activity-dependent manner, BDNF itself did not induce BRINP1-mRNA. From these results, the physiological roles of the activity-dependent induction of BRINP1-mRNA are discussed.

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Section: Introductionmentioning

confidence: 63%

Section: Introductionmentioning

confidence: 82%

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Activity-dependent regulation of BRINP family genes

Motomiya

Kobayashi

Iwasaki

et al. 2007

Biochemical and Biophysical Research Communications

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“…FAM5C was originally identified in the mouse brain as a gene that is induced by the bone morphogenic protein and retinoic acid signaling (BRINP3) (23). BRINP3 is a novel protein of unknown function that is normally restricted to the brain.…”

Section: Discussionmentioning

confidence: 99%

Expression of the FAM5C in tongue squamous cell carcinoma

Kuroiwa

Yamamoto²,

Onda³

et al. 2009

Oncol Rep

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Abstract. The purpose of this study was to perform a wholegenome analysis of loss of heterozygosity (LOH) in tongue squamous cell carcinoma (SCC) using the Affymetrix 10K SNP Mapping Array. In the gene which had been identified by whole-genome analysis of LOH, we analyzed allelic imbalance to identify the role of the gene. We applied wholegenome analysis of LOH in the specimens from the 5 cases of tongue SCC using this array. In the chromosomal region which had been identified by whole-genome analysis of LOH, we reconfirmed the existence of LOH in 30 cases using microsatellite markers. The expression levels of the mRNA in the region were examined in 15 cases and in 5 tongue SCC-derived cell lines by real-time quantitative RT-PCR analysis. LOH was observed in all of the 5 cases in the 1q31.1 region. Only 3 microsatellite markers (D1S1189, D1S2151, and D1S2595) existed in the 1q31.1 region. A high frequency of LOH was found at the D1S1189 locus in 18/30 (60%), D1S2151 locus in 16/30 (53%) and D1S2595 locus in 21/30 (70%). Only the Family with sequence similarity 5, member C (FAM5C) gene was located in the 1q31.1 region. There was statistically significant difference in the FAM5C mRNA expression levels between tongue SCC and normal tissues. All tongue SCC-derived cell lines decreased FAM5C mRNA expression compared with normal oral keratinocytes (NOKs). We conclude that FAM5C may be a novel tumor suppressor gene (TSG) in tongue SCC.

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“…In brain and spinal cord, DBC1 expression is high and some of the homologues have been reported as bone morphogenetic protein-2/retinoic acid-inducible neural-specific proteins (Kawano et al, 2004;Toshiyuki and Ichiro, 2004). Structurally, DBC1 harbours a membrane-attack complex (MAC)/perforin protein domain that, in the context of the perforin protein, is involved in pore formation during complementmediated cell lysis.…”

Section: Introductionmentioning

confidence: 99%

DBC1 re-expression alters the expression of multiple components of the plasminogen pathway

et al. 2005

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Deleted in bladder cancer 1 (DBC1) is a candidate gene for the bladder tumour suppressor locus at 9q33.1. The function of the gene is currently unknown but a crossspecies sequence comparison suggests an important role, as it is highly evolutionarily conserved. Here, we transfected a nonexpressing human bladder cancer cell line with a set of human DBC1 cDNA constructs. The effect on global expression patterns was assessed using cDNA microarrays. The cell clone with the lowest level of DBC1 expression showed induced expression of 26 genes including plasminogen activator inhibitor 2 (SERPINB5; 4.6-fold), heparin-binding EGF-like growth factor precursor (DTR; 4.2-fold), small proline-rich protein 2B (SPRR2B; 3.6-fold), metallothionein 1 isoforms (MT1B/ MT1A/MT-1F; from 2.9-to 3.2-fold), tissue-type plasminogen activator precursor (PLAT; 2.8-fold) and urokinase-type plasminogen activator precursor (PLAU; 2.7-fold). In clustering analysis, both PLAT and PLAU clustered with the functionally related urokinase plasminogen activator surface receptor (PLAUR; 1.9-fold). Furthermore, 14 human bladder tumours were analysed by real-time quantitative PCR using gene-specific primers for selected (n ¼ 20) genes. The expression levels of SERPINB5, PLAU, PLAUR and MT1 correlated with the DBC1 levels, suggesting previously unknown involvement of DBC1 in the urokinase-plasminogen pathway.

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Identification and characterization of novel developmentally regulated neural-specific proteins, BRINP family

Cited by 73 publications

References 46 publications

Activity-dependent regulation of BRINP family genes

Activity-dependent regulation of BRINP family genes

Expression of the FAM5C in tongue squamous cell carcinoma

DBC1 re-expression alters the expression of multiple components of the plasminogen pathway

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