Identification and characterization of interactions between Influenza A Virus NS1 protein and the human ubiquitin proteasome system
Laurie-Anne Lamotte,
Samuel Kindylides,
Chloé Gaupin
et al.
Abstract:As a key player involved in various cellular pathways, including innate immune response activation, the human ubiquitin-proteasome system (UPS) is particularly targeted by viral proteins upon infection. Indeed, most viruses have evolved to counteract and hijack this system, as it is the case for the influenza A virus (IAV). The non-structural protein 1 (NS1) is described as the main IAV virulence factor, which is known to interact with several cellular proteins, including some UPS factors that are important fo… Show more
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