“…Mammalian PcG genes have been identi®ed in mouse and in man and include bmi-1 and mel18, homologs of Drosophila Psc, and Su(2)Z; M33, HPc1, and HPc2, homologs of Drosophila Pc; Rae28/MPh1/ HPh1 and HPh2, homologs of Drosophila Ph; and eed, a Drosophila esc homolog (Tagawa et al, 1990;Haupt et al, 1991;van Lohuizen et al, 1991a,b;Pearce et al, 1992;Satijn et al, 1997;Alkema et al, 1997a;Gunster et al, 1997;Denisenko and Bomsztyk, 1997). The conserved function of these genes has been demonstrated by the homeotic transformation observed in bmi-1 and mel18 transgenic mice as well as by the ability of the mouse M33 gene to complement Pc mutations in Drosophila (van der Lugt et al, 1994;Alkema et al, 1995;Muller et al, 1995;Akasaka et al, 1996).…”