Identification and characterization of circRNAs in Pyrus betulifolia Bunge under drought stress

Wang, Jinxing; Lin, Jing; Wang, Hong; Li, Yong; Yang, Qiyun; Li, Hui; YouHong, Chang

doi:10.1371/journal.pone.0200692

Cited by 30 publications

(15 citation statements)

References 47 publications

(56 reference statements)

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“…CircRNA can bind to miRNAs and compete with endogenous RNA [76]. Therefore, some circRNAs may inhibit or relieve repression of miRNA for translation [77].…”

Section: Discussionmentioning

confidence: 99%

Differential Expression of Circular RNAs in Polytocous and Monotocous Uterus during the Reproductive Cycle of Sheep

Tang

et al. 2019

Animals

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Simple SummaryThe uterus is an important reproductive organ that provides nutrition and place for embryonic development. In this study, we identified circular RNAs by deep sequencing and analyzed their expression in the uteri of polytocous and monotocous sheep (FecB++) during follicular and luteal phases. Gene Ontology (GO) and KEGG enrichment analyses revealed that the source genes of these differential circular RNAs (circRNAs) were mainly enriched in reproductive hormone- and energy metabolism-related pathways. These results provide information on the molecular mechanisms of sheep prolificacy.AbstractCircRNA plays important roles in cell proliferation, differentiation, autophagy and apoptosis during development. However, there are few reports on circRNAs related to livestock reproduction. In this study, we identified circRNAs by deep sequencing and analyzed their expression in the uteri of polytocous and monotocous sheep (FecB++) during follicular and luteal phases. There were 147 and 364 circRNAs with differential expression in the follicular and luteal phases, respectively. GO and KEGG enrichment analysis was performed for the host genes of the circRNAs to predict the functions of differentially expressed circRNAs. These source genes were mainly involved in the estrogen signaling pathway, TGFβ signaling pathway, GnRH signaling pathway, oxytocin signaling pathway, pentose phosphate pathway, and starch and sucrose metabolism related to reproduction and energy metabolism. CircRNA expression patterns were validated by RT-qPCR. Our findings provide a solid foundation for the identification and characterization of key important circRNAs involved in reproduction.

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“…CircRNA can bind to miRNAs and compete with endogenous RNA [76]. Therefore, some circRNAs may inhibit or relieve repression of miRNA for translation [77].…”

Section: Discussionmentioning

confidence: 99%

Differential Expression of Circular RNAs in Polytocous and Monotocous Uterus during the Reproductive Cycle of Sheep

Tang

et al. 2019

Animals

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“…The population of exonic circRNAs differs between plants and even species of the same plant, ranging from ∼6.5 to 86% (Lu et al, 2015;Ye et al, 2015;Wang Z. et al, 2017;Zhao W. et al, 2017;Guria et al, 2019), due to usage of various pipelines, incomplete genome annotations, and other unknown possibilities. Different circRNAs are found to be expressed at different biotic and abiotic stress conditions, as has been proven in plants like O. sativa (Ye et al, 2015), S. lycopersicum (Zuo et al, 2016), A. thaliana (Pan et al, 2018), T. aestivum , P. betulifolia (Wang et al, 2018), A. deliciosa (Wang Z. et al, 2017), and S. tuberosum (Zhou R. et al, 2017), where these circRNAs could act as potential plant biomarkers.…”

Section: Role Of Circrna In Plants So Farmentioning

confidence: 90%

Circular RNAs—The Road Less Traveled

Guria

Sharma

Natesan

et al. 2020

Front. Mol. Biosci.

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Circular RNAs are the most recent addition in the non-coding RNA family, which has started to gain recognition after a decade of obscurity. The first couple of reports that emerged at the beginning of this decade and the amount of evidence that has accumulated thereafter has, however, encouraged RNA researchers to navigate further in the quest for the exploration of circular RNAs. The joining of 5 ′ and 3 ′ ends of RNA molecules through backsplicing forms circular RNAs during co-transcriptional or post-transcriptional processes. These molecules are capable of effectively sponging microRNAs, thereby regulating the cellular processes, as evidenced by numerous animal and plant systems. Preliminary studies have shown that circular RNA has an imperative role in transcriptional regulation and protein translation, and it also has significant therapeutic potential. The high stability of circular RNA is rendered by its closed ends; they are nevertheless prone to degradation by circulating endonucleases in serum or exosomes or by microRNA-mediated cleavage due to their high complementarity. However, the identification of circular RNAs involves diverse methodologies and the delineation of its possible role and mechanism in the regulation of cellular and molecular architecture has provided a new direction for the continuous research into circular RNA. In this review, we discuss the possible mechanism of circular RNA biogenesis, its structure, properties, degradation, and the growing amount of evidence regarding the detection methods and its role in animal and plant systems.

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“…In wheat, Wang et al (2016a) identified 62 circRNAs in response to dehydration stress. Similarly, in pear fruits, 23 circRNAs showed increased expression during drought stress (Wang et al 2018b). Furthermore, the expression of circRNAs in response to bacterial pathogen infection by Pseudomonas syringae pv.…”

Section: Role Of Regulatory Ncrnas In Plant Stress Responsesmentioning

confidence: 93%

Regulatory non-coding RNAs: a new frontier in regulation of plant biology

Bhogireddy

Mangrauthia

Kumar

et al. 2021

Funct Integr Genomics

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Beyond the most crucial roles of RNA molecules as a messenger, ribosomal, and transfer RNAs, the regulatory role of many non-coding RNAs (ncRNAs) in plant biology has been recognized. ncRNAs act as riboregulators by recognizing specific nucleic acid targets through homologous sequence interactions to regulate plant growth, development, and stress responses. Regulatory ncRNAs, ranging from small to long ncRNAs (lncRNAs), exert their control over a vast array of biological processes. Based on the mode of biogenesis and their function, ncRNAs evolved into different forms that include microRNAs (miRNAs), small interfering RNAs (siRNAs), miRNA variants (isomiRs), lncRNAs, circular RNAs (circRNAs), and derived ncRNAs. This article explains the different classes of ncRNAs and their role in plant development and stress responses. Furthermore, the applications of regulatory ncRNAs in crop improvement, targeting agriculturally important traits, have been discussed.

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Identification and characterization of circRNAs in Pyrus betulifolia Bunge under drought stress

Cited by 30 publications

References 47 publications

Differential Expression of Circular RNAs in Polytocous and Monotocous Uterus during the Reproductive Cycle of Sheep

Differential Expression of Circular RNAs in Polytocous and Monotocous Uterus during the Reproductive Cycle of Sheep

Circular RNAs—The Road Less Traveled

Regulatory non-coding RNAs: a new frontier in regulation of plant biology

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