Identification and Characterization of Antioxidants from Sophora flavescens

Piao, Xiang‐Lan; Piao, X. S.; Kim, Sung Woo; Park, Jeong Hill; Kim, Ho; Cai, Shao‐Qing

doi:10.1248/bpb.29.1911

Cited by 56 publications

(60 citation statements)

References 25 publications

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“…12,20-24) Herein, we report some important physical data including 13 C-NMR spectroscopic data. 6 (q, C-9Љ), 111.6 (t, C-10Љ …”

Section: Resultsmentioning

confidence: 99%

“…1 H-and 13 C-NMR as well as 2D-NMR data were obtained on a Bruker AM 500 ( 1 H-NMR at 500 MHz, 13 C-NMR at 125 MHz) spectrometer (Bruker, Karlsruhe, Germany) in either CDCl 3 , acetone-d 6 …”

Section: ) Materials and Methodsmentioning

confidence: 99%

“…8) Biological investigations have mainly focused on its antibacterial, cytotoxic, tyrosinase inhibitory, and glycosidase inhibitory properties. [9][10][11][12] Although the antioxidant benefits of flavonoids from S. flavescens have been reported in a few cases, 13,14) there is no report as to whether the compounds inhibit LDL oxidation and thus their utility toward atherosclerosis treatment is currently not known.…”

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confidence: 99%

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Low Density Lipoprotein (LDL)-Antioxidant Flavonoids from Roots of Sophora flavescens

Jeong

Ryu

Kim

et al. 2008

Biological & Pharmaceutical Bulletin

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Oxidation of low density lipoprotein (LDL) is strongly implicated as a key process in the onset of atherosclerosis. In this study, nine alkylated (C 10 -C 5 ) flavonoids from Sophora flavescens were examined for their inhibitory effects on copper-induced LDL oxidation. Of the flavonoids tested, sophoraflavanone G (1), kurarinone (2), kurarinol (3), norkurarinol (4), and kuraridin (9) inhibited the generation of thiobarbituric acid reactive substances (TBARS) with IC 50 s of 7.9, 14.5, 22.0, 26.9, and 17.5 m mM, respectively. The most potent inhibitor, compound 1, also demonstrated significant activities in complementary in vitro investigations, such as lag time (130 min at 5 m mM), relative electrophoretic mobility (REM) of ox-LDL (80% inhibition at 20 m mM), and fragmentation of apoB-100 (inhibition of 71% at 20 m mM). Analysis of the structures of these compounds reveals that a resorcinol moiety in the B-ring is strongly correlated with protection of LDL-oxidation.

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“…12,20-24) Herein, we report some important physical data including 13 C-NMR spectroscopic data. 6 (q, C-9Љ), 111.6 (t, C-10Љ …”

Section: Resultsmentioning

confidence: 99%

Section: ) Materials and Methodsmentioning

confidence: 99%

mentioning

confidence: 99%

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Low Density Lipoprotein (LDL)-Antioxidant Flavonoids from Roots of Sophora flavescens

Jeong

Ryu

Kim

et al. 2008

Biological & Pharmaceutical Bulletin

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“…So far, more than twenty alkaloids and fifty flavonoids have been isolated and identified (Miao & Zhang, 2001;Zhao & Sun, 2005). The dried roots of Sophora flavescens have various effects like anti-oxidant, anti-inflammation, anti-bacterial, apoptosis modulator properties and anti-tumor activities (Piao et al, 2006;Cheng, et al, 2006;Kuroyanagi et al, 1999;Ko et al, 2000;Zhang & Huang, 2004;Sun et al, 2007).…”

Section: Ethnopharmacological Usementioning

confidence: 99%

A review on phytochemical, ethnomedical and pharmacological studies on genus Sophora, Fabaceae

Krishna¹,

Knv²,

Sandhya³

et al. 2012

Rev. bras. farmacogn.

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Sophora is a genus of the Fabaceae family, contains about 52 species, nineteen varieties, and seven forms that are widely distributed in Asia, Oceanica, and the Pacific islands, in the family Fabaceae of herbaceous (Sophora flavescens Aiton) to trees (Sophora japonica L.). More than fifteen species in this genus have a long history of use in traditional Chinese medicines. In the last decades the use of this genus in traditional Chinese drugs has led to rapid increase in the information available on active components and reported to posses various pharmacological/ therapeutic properties. The paper reviews the ethnopharmacology, the biological activities and the correlated chemical compounds of genus Sophora, Fabaceae. More than 300 compounds has been isolated, among them major are quinolizidine alkaloids particularly matrine and oxymatrine and flavonoids particularly prenylated and isoprenylated flavonoids. Modern pharmacological studies and clinical studies demonstrated that these chemical constituens possess wide reaching pharmacological actions like anti oxidant, anticancer, anti-asthamatic, anti-neoplastic, antimicrobial, antiviral, antidote, anti pyretic, cardiotonic, antinflammatory, diuretic and in the treatment of skin diseases like eczema, colitis and psoriasis.

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“…17) In addition, sophoraflavanone G and kurarinone exhibited protective effects against oxidative damage of the radical generator 2,2Ј-azobis-(2-amidinopropane)-dihydrochloride (AAPH) in renal epithelial LLC-PK(1) cells. 18) Moreover, in a previous study, we demonstrated the antioxidative properties of flavonoids from S. flavescens as 1,1Ј-diphenyl-2-picrylhydrazyl (DPPH) radical and ONOO Ϫ scavengers in vitro. 19) However, the cholesterol-lowering effects of S. flavescens in hyperlipidemic and hypercholesterolemic animal models have not been studied.…”

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confidence: 92%

Hypolipidemic Effects of Sophora flavescens and Its Constituents in Poloxamer 407-Induced Hyperlipidemic and Cholesterol-Fed Rats

Kim

Jeong

Jung

et al. 2008

Biological & Pharmaceutical Bulletin

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In this study, we investigated the hypolipidemic effects of Sophora flavescens in poloxamer 407-induced hyperlipidemic and cholesterol-fed rats. The MeOH extract and 4 fractions of S. flavescens were administered at doses of 250 and 100 mg/kg body weight, respectively, once a day for 3 d to the poloxamer 407-induced hyperlipidemic rats. Serum lipid levels such as total cholesterol (TC), triglycerides (TG), and low-density lipoprotein-cholesterol (LDL-C) were markedly elevated in the poloxamer 407-induced hyperlipidemic control rats, while lipid levels were significantly decreased in the rats administered the MeOH extract or 4 fractions of S. flavescens. In addition, serum high-density lipoprotein-cholesterol (HDL-C) was reduced in the poloxamer 407-induced hyperlipidemic control rats. However, oral administration of both the MeOH extract and 4 fractions significantly increased HDL-C levels. Of the tested fractions, the EtOAc fraction showed the strongest lipid-lowering effect, as well as a high antiatherogenic potential with atherogenic index (A.I.) values of less than 1.92. We also investigated the hypolipidemic effects of the main compounds of the EtOAc fraction, kurarinol and kuraridinol, using the hyperlipidemic and hypercholesterolemic animal models. Here, elevated TC, TG, and LDL-C levels in the poloxamer 407-induced hyperlipidemic and cholesterol-fed rats were significantly reduced after oral administration of the compounds, and HDL-C levels had a significant increase. Furthermore, A.I. values were lowered by administering kurarinol and kuraridinol. In particular, kuraridinol exhibited stronger protective activities against hyperlipidemia than kurarinol. These results suggest that S. flavescens and its constituents may be effective cholesterol-lowering agents and useful for preventing hypercholesterolemic atherosclerosis.

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Identification and Characterization of Antioxidants from Sophora flavescens

Cited by 56 publications

References 25 publications

Low Density Lipoprotein (LDL)-Antioxidant Flavonoids from Roots of Sophora flavescens

Low Density Lipoprotein (LDL)-Antioxidant Flavonoids from Roots of Sophora flavescens

A review on phytochemical, ethnomedical and pharmacological studies on genus Sophora, Fabaceae

Hypolipidemic Effects of Sophora flavescens and Its Constituents in Poloxamer 407-Induced Hyperlipidemic and Cholesterol-Fed Rats

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