Identification and characterization of anti-diabetic principle in Senna alata (Linn.) flower using alloxan-induced diabetic male Wistar rats

Uwazie, Judith N.; Yakubu, Musa Toyin; Ashafa, Anofi Omotayo Tom; Ajiboye, Taofeek O.

doi:10.1016/j.jep.2020.112997

Cited by 19 publications

(9 citation statements)

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“…On the contrary, only emodin exhibited potent intestinal alpha-glucosidase inhibition showing a mixed-type inhibition, which could be of great interest in preventing postprandial glucose spikes. The same results were reported more recently, whereas emodin induced the highest α -glucosidase and α -amylase inhibitory activities in Wistar rats sera [ 89 ]. Emodin treatment of fat C57BL/6 mice reduced body weight gain, improved lipid profile, ameliorated insulin sensitivity, and reduced the size of adipocytes [ 90 ].…”

Section: Main Anthraquinones With Therapeutic Propertiessupporting

confidence: 87%

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An Update of Anthraquinone Derivatives Emodin, Diacerein, and Catenarin in Diabetes

Martorell

Castro

Victoriano

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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Diabetes is part of metabolic diseases and is characterized by high blood sugar levels over a prolonged period as result of an insulin-deficient production or an inappropriate response to insulin by our cells. This chronic disease was the direct cause of 1.6 million deaths in 2016 as reported by the World Health Organization. Emodin is a natural product and active ingredient of various Chinese herbs with the chemical formula 1,3,8-trihydroxy-6-methylanthraquinone. Diacerein is another naturally occurring anthraquinone (1,8-diacetoxy-3-carboxyanthraquinone) commonly used as commercial drug to treat osteoarthritis. These two anthraquinone derivatives have been shown to exert antidiabetic activities. Emodin seems to enhance the glucose tolerance and insulin sensibility via activation of PPARγ and modulation of metabolic-related genes. Diacerein seems to decrease inflammatory cytokines and increase insulin secretion enhancing insulin sensibility and therefore improving glucose control. Other naturally occurring anthraquinone derivatives, such as catenarin (1,4,6,8-tetrahydroxy-3-methylanthraquinone), have been shown to have antidiabetic activities although few studies have been performed. The synthesis of new emodin derivatives is increasing, but these new molecules have not been tested for diabetes treatment. In the current work, available literature on anthraquinone derivatives' effects in diabetes disease is reviewed. Moreover, we discuss the chemistry, food sources, bioavailability, and toxicity of the naturally occurring anthraquinone with antidiabetic effects.

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Section: Main Anthraquinones With Therapeutic Propertiessupporting

confidence: 87%

“…e same results were reported more recently, whereas emodin induced the highest α-glucosidase and α-amylase inhibitory activities in Wistar rats sera [89]. Emodin treatment of fat C57BL/6 mice reduced body weight gain, improved lipid profile, ameliorated insulin sensitivity, and reduced the size of adipocytes [90].…”

Section: Emodin Emodin (Figure 1(b)supporting

confidence: 79%

An Update of Anthraquinone Derivatives Emodin, Diacerein, and Catenarin in Diabetes

Martorell

Castro

Victoriano

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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“…In this work, ZnO NPs were synthesized using leaf extract of Senna Alata L. (SALE), an angiosperm belonging to the family of Fabaceae [25], which contains secondary metabolites in the form of alkaloids, flavonoids, and saponins that act as sources of weak bases, chelating agents, and stabilizing agents during the reaction. Furthermore, ZnO NPs were used to modify the surface of the glassy carbon electrode (GCE).…”

Section: Introductionmentioning

confidence: 99%

Electrochemical activity of glassy carbon electrode modified with ZnO nanoparticles prepared Via Senna Alata L. leaf extract towards antiretroviral drug

Ariyanta

Roji

Apriandanu

2022

Micro and Nano Syst Lett

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The phytosynthesis method was used to prepare ZnO nanoparticles (ZnO NPs) via Senna alata L. leaf extract (SALE) by involving alkaloids, which play an essential role as a source of weak bases during the formation reaction of NPs. ZnO NPs on glassy carbon electrodes (GCE/ZnO NP) have been introduced to investigate its electrochemical activity towards the antiretroviral drug, lamivudine (3TC). Several characterization techniques, such as Fourier Transform Infra-Red (FTIR), X-Ray Diffraction (XRD), Scanning Electron Microscopy (SEM), Energy Dispersive X-Ray Spectroscopy (EDS), and Dynamic Light Scattering (DLS) techniques were employed to analyze the properties of GCE/ZnO NPs. As a result, ZnO NPs in spherical shape showed a high purity crystalline hexagonal wurtzite structure with a particle diameter of 40–60 nm. A Cyclic Voltammetry (CV) measurement confirmed that the electrochemical reduction of 3TC on GCE/ZnO NPs exhibited an excellent linear range of 10–300 µM with a detection limit of 1.902 µM, quantitation limit of 6.330 µM, and sensitivity of 0.0278 µA/µM. Thus, this research suggests a facile method for the preparation of material-based ZnO NPs as a promising antiretroviral drug sensors due to their excellent electrochemical properties.

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“…The crude extracts of S. alata demonstrated broad spectrum of activity against uropathogens. This probably affirmed the traditional usage of S. alata in disease management in Nigeria [18,17].…”

Section: Discussionmentioning

confidence: 53%

“…In traditional medicine, S. alata shows several therapeutic virtues; the decoction of leaves and stem-bark are used to treat dysentery, skin diseases, back ache, constipation and helminthic infection [14,15,16]. In Nigeria, Uwazie et al [17] and Oluwole et al [18] reported that the leaves, stem, and root are used to treat wound, skin diseases, respiratory tract infection, burns, diarrhoea and constipation. Its leaves are used against malaria pathogens [19,20,21,22], skin rashes and mycosis [9,23,24,25], diuretic and purgative [26], wound healing [27,28] and diarrhea [29].…”

Section: Introductionmentioning

confidence: 99%

Studies on the Antibacterial Susceptibility of Uropathogens to Senna alata Extracts in Calabar, Cross River State, Nigeria

Bassey

Alaribe

Ikpi

et al. 2022

ARRB

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Background: Senna alata is an underutilized shrub found in many countries and is known for its traditional use in the treatment of dermatophytes and other related diseases. Therefore, this study aimed at evaluating the phytochemical and antibacterial effects of S. alata leaves extracts against bacterial isolates obtained from urinary tract infection patients in Calabar. Methodology: Matured fresh leaves of Senna alata were collected within Calabar, Cross River state, Nigeria, in May 2022 and identified by a botanist in the Department of Botany, University of Calabar. The leaves of S. alata were extracted with water, methanol and ethyl acetate using maceration and soxhlet methods. Phytochemical analysis was conducted to detect the presence of bioactive compounds using standard methods. The crude extracts of S. alata were investigated for antibacterial properties using agar well diffusion method and mechanisms of antibiosis determined using MBC/MIC ratio. Results: In both methods of extraction, methanol yielded more extracts compared to other solvents. Soxhlet methanol extract (SaMeSh) had the highest (12.21%) percentage yield while maceration ethyl acetate extract (SaEaMa) had the least (4.77%) percentage yield. The phytochemicals assayed revealed the presence of saponins, tannins, flavonoids, anthraquinones, terpenoids and steroids. However, terpenoids was not detected in methanol and ethyl acetate extracts. Senna alata extracts demonstrated broad spectrum of activity against the tested isolates at various concentrations with organic solvents exhibiting the highest antibacterial activity. However, the observed activity varied with respect to concentration of extract and types of organisms. The MIC values ranged from 31.25 to 250 mg/mL and MBC values from 62.5 to 500 mg/mL. The MIC index of the crude extracts against the test uropathogens was ≤8. Conclusion: This study indicates that S. alata could be a source of novel antimicrobial agent. Further research is required to isolate, characterize and identify bioactive constituents responsible for the observed activity.

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Identification and characterization of anti-diabetic principle in Senna alata (Linn.) flower using alloxan-induced diabetic male Wistar rats

Cited by 19 publications

References 50 publications

An Update of Anthraquinone Derivatives Emodin, Diacerein, and Catenarin in Diabetes

An Update of Anthraquinone Derivatives Emodin, Diacerein, and Catenarin in Diabetes

Electrochemical activity of glassy carbon electrode modified with ZnO nanoparticles prepared Via Senna Alata L. leaf extract towards antiretroviral drug

Studies on the Antibacterial Susceptibility of Uropathogens to Senna alata Extracts in Calabar, Cross River State, Nigeria

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