Identification and characterization of a novel antisense RNA transcribed from the opposite strand of the human blood group <i>ABO</i> gene

Hata, Yukiko; Kominato, Yoshihiko; Takizawa, Hisao

doi:10.1111/j.1537-2995.2007.01198.x

Cited by 13 publications

(8 citation statements)

References 26 publications

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“…Approximately two‐thirds of these publications, however, would outright qualify as “molecular.” 29‐80 Many molecular immunohematology publications addressed routine clinical applications 29‐39 and clinical consequences 36‐43 . A large number of publications on basic transfusion medicine research topics 43‐76 document the need to explore genetic features and to collate the allelic variety present within and among the various populations worldwide 29,42,44,46‐54,71,73 . A Workshop on Molecular Methods in Immunohematology was sponsored in September 2006 by Food and Drug Administration (FDA)/Center for Biologics Evaluation and Research, Department of Health and Human Services Office of the Secretary/Office of Public Health and Science, National Institutes of Health/National Heart, Lung, and Blood Institute.…”

Section: Molecular Methods In Immunohematologymentioning

confidence: 99%

Applying molecular immunohematology discoveries to standards of practice in blood banks: now is the time

Denomme

Flegel

2008

Transfusion

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Lessons from more than 100 years of immunohematology exemplify that many critical discoveries were made serendipitously and their more rapid implementation could have benefited transfusion recipients and pregnancies. Constituents of blood that are not essential for the attempted therapeutic benefit of a transfusion are largely removed from today's blood products. We are now moving on to avoid unnecessary exposure to potentially harmful constituents of the therapeutically required cells, like blood group antigens that are foreign to the patient. Cost efficacy needs to be kept in mind but may eventually prove much better than anticipated, once hidden benefits are captured, as we show by examples from past immunohematologic developments. Here, we detail clinical applications for molecular immunohematology advances including "dry-matching" that will improve transfusion outcomes and argue for their widespread implementation by rapid timelines through standards of practice.

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Section: Molecular Methods In Immunohematologymentioning

confidence: 99%

Applying molecular immunohematology discoveries to standards of practice in blood banks: now is the time

Denomme

Flegel

2008

Transfusion

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“…Vol. 66,2009 Review Article 105 At least part of this transcriptional cellular memory appears to rely upon chromatin-remodeling proteins that play an integral role in epigenetic regulation and maintenance of the Hox expression pattern [163,229]. Two opposing groups of histone-modifying complexes, the trithorax group (TrxG) and the Polycomb group (PcG) proteins, have been implicated in maintaining this cellular memory as regions of open and closed chromatin domains in the Hox loci [230].…”

Section: Review Articlementioning

confidence: 99%

Antisense transcription: A critical look in both directions

Beiter

Reich

Williams

et al. 2008

Cell. Mol. Life Sci.

107

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The mammalian genome contains a large layer of hidden biological information. High-throughput methods have provided new insights into the regulatory networks that orchestrate the "when, where and how" of gene expression, revealing a complex interplay between proteins, regulatory RNAs, and chemical and structural alterations of the genome itself. Naturally occurring antisense transcription has been considered as an important feature in creating transcriptional and hence cellular and organismal complexity. Here, we review the current understanding of the extent, functions and significance of antisense transcription. We critically discuss results from genome-wide studies and documented examples of individual antisense transcripts. So far, the regulatory potential of gene overlaps has been demonstrated only in a few selected cases of experimentally characterized antisense transcripts. Facing the large-scale antisense transcription observed in eukaryotic genomes, it still remains an open challenge to distinguish transcriptional noise from biological function of gene overlapping patterns.

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“…The best known examples of epigenetic regulation of gene expression include DNA methylation of CpG islands in gene promoter regions, chromatin alterations (i.e. histone acetylation, methylation, and ubiquitylation) and the expression of non-coding RNAs (312)(313)(314). The relevance of these modifications in cancer progression is increasingly recognized and the mutual interplay among these mechanisms is emerging as a novel paradigm of gene regulation (315).…”

Section: Epigenetic Regulationmentioning

confidence: 99%

Mechanisms of cancer-associated glycosylation changes

Dall’Olio

Malagolini²,

Trinchera³

et al. 2012

Front Biosci

137

102

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Cell membrane glycoconjugates undergo characteristic changes as a consequence of neoplastic transformation. The cancer-associated carbohydrate structures play key roles in cancer progression by altering the cell-cell and cell-environment interactions. In this review, we will discuss some of the most relevant cancer-associated carbohydrate structures, including the β1,6-branching of N-linked chains, the sialyl Lewis antigens, the α2,6-sialylated lactosamine, the Thomsen-Friedenreich-related antigens and gangliosides. We will describe the mechanisms leading to the expression of these structures and their interactions with sugar binding molecules, such as selectins and galectins. Finally, we will discuss how the glycosylation machinery of the cell is controlled by signal transduction pathways, epigenetic mechanisms and responds to hypoxia.

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Identification and characterization of a novel antisense RNA transcribed from the opposite strand of the human blood group ABO gene

Abstract: These results suggest that ABOAS transcribed from the opposite strand of the ABO gene might be involved in the regulation of ABO gene expression.

Cited by 13 publications

References 26 publications

Applying molecular immunohematology discoveries to standards of practice in blood banks: now is the time

Applying molecular immunohematology discoveries to standards of practice in blood banks: now is the time

Antisense transcription: A critical look in both directions

Mechanisms of cancer-associated glycosylation changes

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