Identification and Characterization of a Papillomavirus from Birds (Fringillidae)

Osterhaus, Albert D. M. E.; Ellens, D. J.; Horzinek, Marian C.

doi:10.1159/000148910

Cited by 35 publications

(19 citation statements)

References 13 publications

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“…The well characterised papillomavirus FPV was demonstrated in leg papillomas of chaffinches (Jennings, 1968;Lina, 1970;Lina et al, 1973). The agent was characterised as a papillomavirus by its size and density of virus particles, physical properties of viral DNA, and results of electrophoretic analyses of capsid proteins (Lina, 1970;Osterhaus et al, 1977). The cloned FPV genome showed some homology with genomes of mammalian papillomaviruses in hybridisation studies and partial sequence analyses (Moreno-Lopez et al, 1984).…”

Section: Discussionmentioning

confidence: 99%

Papillomatosis in chaffinches (Fringilla coelebs) in the Czech Republic and Germany

Literák¹,

Smíd²,

Valíček³

2003

Vet. Med. - Czech

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Analyses of ornithological field records, direct observations of typical lesions, and examination by electron microscopy revealed leg papillomatosis in six chaffinches (Fringilla coelebs) in theCzech Republic and one chaffinch inGermany. Papillomavirus was identified by electron microscopy using the negative staining technique in skin lesions of one chaffinch caught in theCzechRepublic. This is the first report of papillomatosis in chaffinches recorded in theCzechRepublic.

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Section: Discussionmentioning

confidence: 99%

Papillomatosis in chaffinches (Fringilla coelebs) in the Czech Republic and Germany

Literák¹,

Smíd²,

Valíček³

2003

Vet. Med. - Czech

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Section: Abstract Birds Histocytochemistry Chondrocytes Papillomavmentioning

confidence: 99%

“…46 Avian papillomaviruses have been described in more than 12 avian species and 6 orders 27 since the 1970s. 28,33 In that time, only 3 have been fully sequenced: Francolinus leucoscepus papillomavirus 1 (FlPV1), Psittacus erithacus papillomavirus (PePV), and Fringilla coelebs papillomavirus (FcPV).31,41,44 Among species described so far, avian papillomaviruses and mammalian papillomaviruses share epitheliotropism and similar tissue distribution. In psittacines, virus has been detected in intestinal mucosal cells, 13,16,19,23,27,30,40 nasolacrimal epithelium, 13,16,22 and oral mucosa at the commissure of beaks.…”

mentioning

confidence: 99%

Identification of a Novel Papillomavirus in a Northern Fulmar (Fulmarus glacialis) With Viral Production in Cartilage

Gaynor

Fish

Duerr³

et al. 2014

Vet Pathol

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We report the identification of a novel papillomavirus, Fulmarus glacialis papillomavirus 1 (FgPV1), present within an interdigital foot mass of a Northern Fulmar (Fulmarus glacialis). The mass of interest was composed of normal stratified and keratinized epithelium and dense mesenchymal cells with central cartilaginous islands. Within the nuclei of many chondrocytes were loose aggregates or paracrystalline arrays of virions approximately 50 nm in size. Degenerate polymerase chain reaction was used to identify the virus as a putative papillomavirus, and the entire viral genome of 8132 base pairs was subsequently amplified and sequenced. Analysis revealed canonical papillomavirus architecture, including the early open reading frames E6, E7, E1, and E2 and the 2 late proteins L1 and L2. FgPV1 is most closely related to a cluster of avian and reptilian papillomaviruses as visualized by phylogenetic trees. This observation suggests that papillomavirus virion production can occur in mesenchymal cells. Keywords birds, histocytochemistry, chondrocytes, papillomavirus infections, inclusion bodies-viral, transmission electron microscopy, genome-viralThe Papillomaviridae family continues to expand with the ongoing discovery of previously unidentified species occupying over 30 different genera. 46 Avian papillomaviruses have been described in more than 12 avian species and 6 orders 27 since the 1970s. 28,33 In that time, only 3 have been fully sequenced: Francolinus leucoscepus papillomavirus 1 (FlPV1), Psittacus erithacus papillomavirus (PePV), and Fringilla coelebs papillomavirus (FcPV).31,41,44 Among species described so far, avian papillomaviruses and mammalian papillomaviruses share epitheliotropism and similar tissue distribution. In psittacines, virus has been detected in intestinal mucosal cells, 13,16,19,23,27,30,40 nasolacrimal epithelium, 13,16,22 and oral mucosa at the commissure of beaks. 22There is also a report of papillomavirus-associated growths on the legs and feet of two related finch species, Fringilla. coelebs and Fringilla montifringilla. 31 To date, there have been no reports of papillomaviruses or any neoplastic lesions in free-ranging seabirds despite the identification of papillomaviruses in numerous marine mammals, 5,35 including dolphins, 36,37 porpoises, 43 and sea turtles. 18Regardless of host species, productive papillomavirus infection (formation of infectious particles) has been invariably tied to the terminal differentiation of epithelial cells. A small number of papillomaviruses are capable of infecting and transforming fibroblasts, but these infections are considered nonproductive. The members of the Deltapapillomavirus genus such as bovine (Bos taurus) papillomaviruses 1 and 2 (BPV1, BPV2), for example, can infect fibroblasts in cattle, horses, and cats and is associated with transformation in these cells, causing the formation of fibropapillomas, also known as sarcoids in nonbovid species. 20 In these cases, virion production is considered limited to infected cells within the o...

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“…The reported incidence of external neoplasms in wild birds is low, except for squamous papillomas found on the foot and lower leg of chaffinches (Fringilla coelebs) (13). The causative agent of these lesions was characterized as a PV based on the size and density of virus particles, physical properties of viral DNA, and analysis of capsid proteins by electrophoresis (20). The other known PV infection among avian species was in an African gray parrot (Psittacus erithacus timneh) (12).…”

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confidence: 99%

Lack of Canonical E6 and E7 Open Reading Frames in Bird Papillomaviruses: Fringilla coelebs Papillomavirus and Psittacus erithacus timneh Papillomavirus

Terai¹,

DeSalle

Burk

2002

J Virol

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Determination and analyses of the complete sequence of Fringilla coelebs papillomavirus and Psittacus erithacus timneh papillomavirus indicate that they represent a distinct and distant lineage of papillomaviruses. The lack of canonical E6-E7 open reading frames suggests that they serve adaptive functions during papillomavirus evolution.Papillomaviruses (PVs) are a heterogeneous group of DNA viruses with closed-circular double-stranded DNA genomes about 8 kb in size. They are highly species-specific pathogens and cause benign and malignant lesions of squamous and mucosal epithelium in a wide range of animal species (22). The reported incidence of external neoplasms in wild birds is low, except for squamous papillomas found on the foot and lower leg of chaffinches (Fringilla coelebs) (13). The causative agent of these lesions was characterized as a PV based on the size and density of virus particles, physical properties of viral DNA, and analysis of capsid proteins by electrophoresis (20). The other known PV infection among avian species was in an African gray parrot (Psittacus erithacus timneh) (12). The PV genomes isolated from a chaffinch and an African gray parrot were cloned and partially sequenced (16, 18). We have determined and characterized the complete sequences of F. coelebs PV (FPV) and P. erithacus timneh PV (PePV).The FPV genome was cloned into the EcoRI site of pBR328, and the PePV genome was cloned into the SalI site of pBR322 (16,18). To determine the nucleotide sequence, each cloned DNA was sequenced with the first primers selected from the vector sequence, and thereafter, additional primers were designed by sequence walking (7). Sequencing was performed in the Albert Einstein College of Medicine DNA sequencing core facility. The overlapping sequences were assembled manually. Several additional primers were designed and used to clarify sequence ambiguities. Once assembled, the sequence was analyzed for similarity to other PVs by using the basic local alignment sequence tool (BLAST) software (1). The same software was used to determine protein sequence similarities.The assembled sequences revealed a total size of 7,729 bp for FPV and 7,304 bp for PePV. The complete sequences of the genomes are available from the GenBank database under accession no. AY057109 (FPV) and AF420235 (PePV). Examination of the FPV and PePV sequences for potential genes showed the typical complement of E1, E2, L2, and L1 open reading frames (ORFs) comparable in size with, and at positions similar to, those of other PVs, including overlaps between the E1 and E2 and the L2 and L1 ORFs. None of the small ORFs in FPV and PePV showed significant similarity with sequences for known E4 and E5 proteins. The PePV long control region contains one exact 12-bp E2-binding motif, whereas the FPV long control region contains four E2-binding motifs with one base pair mismatch. The predicted ORFs of FPV and PePV are shown in Fig. 1. The similarity of the FPV and PePV L1 ORF nucleotide and amino acid sequences was higher (nucleotide, 56.8%...

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Identification and Characterization of a Papillomavirus from Birds (Fringillidae)

Cited by 35 publications

References 13 publications

Papillomatosis in chaffinches (Fringilla coelebs) in the Czech Republic and Germany

Papillomatosis in chaffinches (Fringilla coelebs) in the Czech Republic and Germany

Identification of a Novel Papillomavirus in a Northern Fulmar (Fulmarus glacialis) With Viral Production in Cartilage

Lack of Canonical E6 and E7 Open Reading Frames in Bird Papillomaviruses: Fringilla coelebs Papillomavirus and Psittacus erithacus timneh Papillomavirus

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