Identification and characterization of a vitamin D3 decomposition product bactericidal against Helicobacter pylori

Abstract

This study demonstrated that the vitamin D3 decomposition product VDP1 exerts an antibacterial action against Helicobacter pylori but not against other bacteria. Treatment with VDP1 induced a collapse of cell membrane structures of H. pylori and ultimately lysed the bacterial cells. A unique dimyristoyl phosphatidylethanolamine in the membrane lipid compositions contributed to the interaction of VDP1 with H. pylori cells. In separate experiments, VDP1 had no influence on the viability of the human cancer cell lines MKN45 and T47D and lacked any vitamin D3-like hormonal action against the latter. In both 1H and 13C NMR analyses, the spectra patterns of VDP1 corresponded with those of Grundmann's ketone. These results suggest that VDP1 (or Grundmann's ketone-type indene compound) may become a fundamental structure for the development of new antibacterial substances with selective bactericidal action against H. pylori.

Severe electrolytes disorders with the interstitial kidney alterations in the patient with the history of total thyroidectomy and parathyroidectomy: possible role of vitamin D deficiency

“…Similar trend has been reported in worldwide . In general, vitamin D is recognized as vital molecule in the homeostasis of calcium and phosphate levels; vitamin D deficiency has been implicated in the diverse pathological conditions such as hypomagnesemia , auto‐antibodies induction , and Helicobacter pylori infection .…”

“…Vitamin D deficiency was shown to be associated with increased autoimmune responses . Moreover, the induction of auto‐antibodies found in this patient could be associated with the H. pylori infection , and vitamin D deficiency could potentiate the host to H. pylori infection . Careful follow‐up is continuously required.…”

Influence of serum vitamin D level on Helicobacter pylori eradication: A multi‐center, observational, prospective and cohort study

“…Several clinical studies have illustrated that vitamin D analogs may have anti‐ H. pylori antimicrobial effects . Cytological research has also found that vitamin D 3 decomposition product 1 (VDP1) can lyse H. pylori bacterial cells by inducing the collapse of the cell membrane …”

The influence of vitamin D deficiency on eradication rates of Helicobacter pylori

“…One in vitro study showed the selective antibacterial effect of vitamin D3 decomposition product (VDP1) against H.pylori. 27 Vitamin D is also known to regulate the expression of antimicrobial peptides -cathelicidin and β-defensin, which kill the bacteria. Although the effect of cathelicidin has been demonstrated only in macrophages infected with M. tuberculosis, antibacterial action against gram-negative and gram-positive bacteria has also been reported.…”