Identification and characterisation of peptides from a boarfish (Capros aper) protein hydrolysate displaying in vitro dipeptidyl peptidase-IV (DPP-IV) inhibitory and insulinotropic activity

Harnedy‐Rothwell, Pádraigín A.; McLaughlin, Chris M.; O’Keeffe, Martina B.; Gouic, Aurélien V. Le; Allsopp, Philip J.; McSorley, Emeir M.; Sharkey, Shaun J; Whooley, Jason; McGovern, Brian; O’Harte, Finbarr; Fitzgerald, Richard J.

doi:10.1016/j.foodres.2020.108989

Cited by 62 publications

(62 citation statements)

References 40 publications

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“…Thus, Harnedy-Rothwell et al identified IPVDM as the third-most potent food-derived DPP-4 inhibitor discovered to date, with an IC 50 of 21.7 µm. [85] Alongside this strong evidence for DPP-4 inhibitory action, several studies have also shown FPH to have strong insulin, GLP-1, and CCK release actions. [31][32][33]39,40,85,86] The in vivo efficacy of FPH has also been reasonably well established.…”

Section: Discussionmentioning

confidence: 94%

“…[85] Alongside this strong evidence for DPP-4 inhibitory action, several studies have also shown FPH to have strong insulin, GLP-1, and CCK release actions. [31][32][33]39,40,85,86] The in vivo efficacy of FPH has also been reasonably well established. Acutely, all studies investigating an anti-hyperglycemic effect of FPH has found a reduction in blood glucose with doses as low as 50 mg kg −1 bodyweight, [33] and several exhibiting an increase in plasma insulin [33,34] or GLP-1 [34] ; however, Iba et al [34] used extremely high doses of 1.5 g kg −1 and 3 g kg −1 bodyweight which would be impossible to translate to a human trial.…”

Section: Discussionmentioning

confidence: 94%

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A Narrative Review of the Anti‐Hyperglycemic and Satiating Effects of Fish Protein Hydrolysates and Their Bioactive Peptides

Sharkey

Harnedy‐Rothwell

Allsopp

et al. 2020

Molecular Nutrition Food Res

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Prevalence of type 2 diabetes and overweight/obesity are increasing globally. Food supplementation as a preventative option has become an attractive option in comparison to increased pharmacotherapy dependency. Hydrolysates of fish processing waste and by-products have become particularly interesting in a climate of increased food wastage awareness and are rapidly gaining traction in food research. This review summarizes the available research so far on the potential effect of these hydrolysates on diabetes and appetite suppression. Scopus and Web of Science are searched using eight keywords (fish, hydrolysate, peptides, satiating, insulinotropic, incretin, anti-obesity, DPP-4 [dipeptidylpeptidase-4/IV]) returning a total of 2549 results. Following exclusion criteria (repeated appearances, non-fish marine sources [e.g., macroalgae], and irrelevant bioactivities [e.g., immunomodulatory, anti-thrombotic]), 44 relevant publications are included in this review. Stimulation of hormone secretion, regulation of glucose uptake, anorexigenic potential, identified mechanisms of action, and research conducted on the most potent bioactive peptides identified within these hydrolysates are all specifically addressed. Results of this review conclude that despite wide methodological variation between studies, there is significant potential for the application of fish protein hydrolysates in the management of bodyweight and hyperglycemia.

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Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 94%

A Narrative Review of the Anti‐Hyperglycemic and Satiating Effects of Fish Protein Hydrolysates and Their Bioactive Peptides

Sharkey

Harnedy‐Rothwell

Allsopp

et al. 2020

Molecular Nutrition Food Res

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“…In terms of large-scale production, some authors have produced protein hydrolysates at a pilot or semi-pilot plant scale. In this context, different hydrolysates have been produced from such sources as fish discards [58] for their valorization, and trials have confirmed the results of production obtained at lab scale, or from boarfish [59], which show strong DPP-IV inhibitory activities.…”

Section: Enzymatic Hydrolysis Reactionmentioning

confidence: 85%

“…The literature reporting fish peptides with antidiabetic activity has been recently stated [59,[81][82][83]. In this context, the use of fishing discards as protein sources for value-added products is important [55,59,83,84]. The scientific community considers enzymatic hydrolysis as a helpful option for revaluing these low-quality products and increasing their potential, as they have no side effects on the patient's health.…”

Section: Protein Sourcementioning

confidence: 99%

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Antidiabetic Food-Derived Peptides for Functional Feeding: Production, Functionality and In Vivo Evidences

Rivero‐Pino

Espejo-Carpio

Guadix

2020

Foods

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Bioactive peptides released from the enzymatic hydrolysis of food proteins are currently a trending topic in the scientific community. Their potential as antidiabetic agents, by regulating the glycemic index, and thus to be employed in food formulation, is one of the most important functions of these peptides. In this review, we aimed to summarize the whole process that must be considered when talking about including these molecules as a bioactive ingredient. In this regard, at first, the production, purification and identification of bioactive peptides is summed up. The detailed metabolic pathways described included carbohydrate hydrolases (glucosidase and amylase) and dipeptidyl-peptidase IV inhibition, due to their importance in the food-derived peptides research field. Then, their characterization, concerning bioavailability in vitro and in situ, stability and functionality in food matrices, and ultimately, the in vivo evidence (from invertebrate animals to humans), was described. The future applicability that these molecules have due to their biological potential as functional ingredients makes them an important field of research, which could help the world population avoid suffering from several diseases, such as diabetes.

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Production of Antidiabetic Peptides from Fish Waste

Rivero-Pino,

Espejo-Carpio,

García-Moreno

et al. 2024

Fish Waste to Valuable Products

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Identification and characterisation of peptides from a boarfish (Capros aper) protein hydrolysate displaying in vitro dipeptidyl peptidase-IV (DPP-IV) inhibitory and insulinotropic activity

Cited by 62 publications

References 40 publications

A Narrative Review of the Anti‐Hyperglycemic and Satiating Effects of Fish Protein Hydrolysates and Their Bioactive Peptides

A Narrative Review of the Anti‐Hyperglycemic and Satiating Effects of Fish Protein Hydrolysates and Their Bioactive Peptides

Antidiabetic Food-Derived Peptides for Functional Feeding: Production, Functionality and In Vivo Evidences

Production of Antidiabetic Peptides from Fish Waste

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